Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma.
Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma.
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纤维蛋白凝胶增强胶质母细胞瘤中嵌合抗原受体 T 细胞的抗肿瘤作用。
DOI：
10.1126/sciadv.abg5841
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发表时间：
2021-10-08
期刊：
影响因子：
13.6
通讯作者：
Dotti G
中科院分区：
文献类型：
--
作者：
Ogunnaike EA;Valdivia A;Yazdimamaghani M;Leon E;Nandi S;Hudson H;Du H;Khagi S;Gu Z;Savoldo B;Ligler FS;Hingtgen S;Dotti G
In situ fibrin gel promotes the survival and the biodistribution of CAR-T cells, eliminating residual GBM cells after surgery. Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.
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影响因子：
17.1
作者：
Pellegatta S;Savoldo B;Di Ianni N;Corbetta C;Chen Y;Patané M;Sun C;Pollo B;Ferrone S;DiMeco F;Finocchiaro G;Dotti G
通讯作者：
Dotti G
影响因子：
11.1
作者：
Nehama, Dean;Di Ianni, Natalia;Dotti, Gianpietro
通讯作者：
Dotti, Gianpietro
影响因子：
50.3
作者：
Sun, Chuang;Shou, Peishun;Dotti, Gianpietro
通讯作者：
Dotti, Gianpietro
影响因子：
51.1
作者：
Weller, Michael;Butowski, Nicholas;Sampson, John H.
通讯作者：
Sampson, John H.
影响因子：
20.3
作者：
Vera, Juan;Savoldo, Barbara;Dotti, Gianpietro
通讯作者：
Dotti, Gianpietro