Dispacamides, anti-histamine alkaloids from Caribbean Agelas sponges
Dispacamides, anti-histamine alkaloids from Caribbean Agelas sponges
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DOI：
10.1016/0040-4039(96)00629-6
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发表时间：
1996-05-13
影响因子：
1.8
通讯作者：
TaglialatelaScafati, O
中科院分区：
文献类型：
--
作者：
Cafieri, F;Fattorusso, E;TaglialatelaScafati, O
二异丙酰胺1及其单溴衍生物2是一类新的含氨基咪唑啉酮的溴吡咯生物碱。它们是从四种加勒比海Agelas海绵（A. conifera、松叶蜂A. longissima、长柄草A. clathrodes，A. dispar），并基于光谱数据阐明了它们的结构。化合物1和2在豚鼠回肠上显示出显著的选择性抗组胺活性。版权所有（C）1996 Elsevier Science Ltd
Dispacamide 1 and its monobromo derivative 2, are novel bromopyrrole alkaloids containing an aminoimidazolone moiety. They were isolated from four Caribbean Agelas sponges (A. conifera, A. longissima, A. clathrodes, A. dispar), and their structures elucidated on the basis of spectroscopic data. Compounds 1 and 2 exhibit remarkably selective antihistamine activity, tested on the guinea pig ileum. Copyright (C) 1996 Published by Elsevier Science Ltd