Larval melanocyte regeneration following laser ablation in zebrafish
Larval melanocyte regeneration following laser ablation in zebrafish
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DOI：
10.1111/j.0022-202x.2004.23475.x
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发表时间：
2004-11-01
影响因子：
6.5
通讯作者：
Johnson, SL
中科院分区：
文献类型：
--
作者：
Yang, CT;Sengelmann, RD;Johnson, SL
一种在遗传易感生物中特异性切除黑素细胞的方法将有助于分析黑素细胞的再生和调控。我们已经证明了q开关钕钇铝石榴石皮肤病激光杀死斑马鱼的幼虫黑色素细胞。黑素细胞消融后，新的黑素细胞从未着色的前体再生。我们发现激光消融后黑素细胞再生需要kit受体酪氨酸激酶。
A method to specifically ablate melanocytes in a genetically tractable organism would facilitate the analysis of melanocyte regeneration and regulation. We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology laser kills larval melanocytes in zebrafish. Following melanocyte ablation, new melanocytes regenerate from unpigmented precursors. We show that melanocyte regeneration following laser ablation requires kit receptor tyrosine kinase.