Anti-mechanical allodynic effect of intrathecal and intracerebroventricular injection of orexin-A in the rat neuropathic pain model
Anti-mechanical allodynic effect of intrathecal and intracerebroventricular injection of orexin-A in the rat neuropathic pain model
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DOI：
10.1016/s0304-3940(03)00716-x
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发表时间：
2003-08
影响因子：
2.5
通讯作者：
Tatsuo Yamamoto;O. Saito;K. Shono;T. Aoe;T. Chiba
中科院分区：
文献类型：
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作者：
Tatsuo Yamamoto;O. Saito;K. Shono;T. Aoe;T. Chiba
据报道，Orexin-A 在热板试验和炎性疼痛模型中具有镇痛作用。在本研究中，作者检查了 orexin-A 对大鼠部分坐骨神经结扎（神经性疼痛模型）引起的机械异常性疼痛的影响。部分坐骨神经结扎是通过紧密结扎右侧坐骨神经的三分之一或二分之一来实现的。部分坐骨神经损伤后 7 天，通过鞘内或脑室内给予 Orexin-A。鞘内或脑室内注射食欲素-A 可减轻部分坐骨神经结扎引起的机械异常性疼痛的水平。这些数据表明，鞘内或脑室内注射食欲素-A是治疗神经损伤引起的机械性异常性疼痛的新治疗方法。
Orexin-A has been reported to produce an analgesic effect in the hot plate test and in the inflammatory pain models. In the present study, the authors examined the effect of orexin-A on the mechanical allodynia induced by partial sciatic nerve ligation (a model of neuropathic pain) in the rat. Partial sciatic nerve ligation is created by tight ligation of one-third or one-half of the right sciatic nerve. Orexin-A was administered intrathecally or intracerebroventricularly 7 days after a partial sciatic nerve injury. Either intrathecal or intracerebroventricular injection of orexin-A attenuated the level of mechanical allodynia induced by partial sciatic nerve ligation. These data suggest that either intrathecal or intracerebroventricular injection of orexin-A is a new therapeutic approach to treating mechanical allodynia caused by nerve injury.