Seasonal changes in the tetrodotoxin content of the pufferfish Takifugu niphobles
Seasonal changes in the tetrodotoxin content of the pufferfish Takifugu niphobles
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DOI：
10.1016/j.toxicon.2016.02.020
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发表时间：
2016-05-01
期刊：
影响因子：
2.8
通讯作者：
Sugita, Haruo
中科院分区：
文献类型：
--
作者：
Itoi, Shiro;Ishizuka, Kento;Sugita, Haruo
为了调查河豚毒素(TTX)全身含量和组织分布的季节变化，2010年11月至2012年5月从三浦半岛周边海域采集野生个体，对其组织进行LC-MS/MS分析。性成熟的鱼被分为成熟期（四月）、产卵期（五月、七月）或“普通期”（即其他月份）。在两性中，性腺体细胞指数在成熟期迅速增加，然后在产卵期下降。成熟/产卵期全身TTX含量显着高于正常时期。在所有季节中，TTX 定位于雌性的皮肤或卵巢，以及雄性的皮肤或肝脏：雌性和雄性之间 TTX 定位的差异在产卵期间尤其明显。 (C) 2016 Elsevier Ltd. 保留所有权利。
To investigate seasonal changes in the whole body content and tissue distribution of tetrodotoxin (TTX) in the pufferfish Takifugu niphobles, wild individuals were collected from the coastal waters around Miura Peninsula from November 2010 to May 2012, and their tissues were subjected to LC-MS/MS analysis. Fish that were sexually mature were classified as being in the maturation period (April), the spawning period (May July) or the "ordinary period" (i.e., other months). In both sexes, gonad somatic index rapidly increased during the maturation period and then decreased during the spawning period. Whole body TTX content was significantly higher during the maturation/spawning period than in the ordinary period. Through all seasons, TTX was localized in the skin or ovary in females and in the skin or liver in males: the difference in TTX localization between females and males was particularly evident during the spawning period. (C) 2016 Elsevier Ltd. All rights reserved.