Effect of arterial hypotension on anaesthetic requirement in dogs.
Effect of arterial hypotension on anaesthetic requirement in dogs.
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DOI：
10.1093/bja/48.10.947
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发表时间：
1976-10
影响因子：
9.8
通讯作者：
Y. Tanifuji;E. Eger
中科院分区：
文献类型：
--
作者：
Y. Tanifuji;E. Eger
在犬中，平均动脉压降至40-50 mm Hg时，第1小时MAC下降20+/-EM 4%。在随后的3小时低血压（40-50 mm Hg）期间没有进一步的变化。动脉和脑脊液乳酸和丙酮酸浓度不受低血压的影响，也没有脑脊液pH值下降。在另一组狗中，我们依次将动脉压降低至40-50、30-40和20-30 mm Hg。MAC随之降低，在最低压力下为对照值的58+/-11%。恢复正常压力后，MAC增加，但滞后是明显的。在第三组狗中，动脉压迅速降低至10-30 mm Hg。MAC降至对照组的29+/-5%。这一下降幅度明显大于与三阶段减少相关的下降幅度。
In the dog a reduction of mean arterial pressure to 40-50 mm Hg decreased MAC by 20+/--EM 4% in the 1st hour. No further change resulted during the ensuing 3 h of hypotension (40-50 mm Hg). Arterial and cerebrospinal fluid lactate and pyruvate concentrations were not affected by hypotension, nor did cerebrospinal fluid pH decrease. In a separate group of dogs, we reduced arterial pressure to 40-50, 30-40 and 20-30 mm Hg successively. MAC decreased concomitantly, being 58+/-11% of control value at the lowest pressure. MAC increased following the restoration of normal pressure, but hysteresis was evident. In a third group of dogs, arterial pressure was reduced rapidly to 10-30 mm Hg. MAC decreased to 29+/-5% of control. This decrease was significantly greater than that associated with the three-stage reduction.