Effect of postprandial modulation of glucose availability: short- and long-term analysis
Effect of postprandial modulation of glucose availability: short- and long-term analysis
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DOI：
10.1017/s0007114509993357
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发表时间：
2010-05-28
影响因子：
3.6
通讯作者：
Laville, Martine
中科院分区：
文献类型：
--
作者：
Nazare, Julie-Anne;de Rougemont, Alexis;Laville, Martine
低血糖指数（LOT）食物被认为是减少餐后血糖波动的潜在手段，从而改善糖尿病管理。我们调节谷物产品的葡萄糖利用率，从而调节其血糖指数，以研究LGI食物对自由生活受试者为期5周的GI干预饮食后全天血糖控制的急性和长期代谢效应。在这项随机、平行试验中，两组19名超重受试者接受了为期5周的随意干预饮食，其中普通淀粉被LGI或高GI（HGI）淀粉替代。在探索日（第1天和第36天）期间，受试者食用分配的DC标记的测试早餐（LGI或HGI），并在测试早餐和标准化午餐后评估总葡萄糖和外源性葡萄糖动力学（使用稳定同位素）、葡萄糖、胰岛素的餐后浓度、血脂谱和营养氧化。在第一天。LGI早餐显著降低了早餐后的血糖反应，同时降低了外源性葡萄糖和总葡萄糖的出现（P
Low glycaemic index (LOT) foods have been proposed as potential means to decrease postprandial glucose excursions and thus to improve diabetes management. We modulated glucose availability of cereal products and thus their glycaemic index to study the metabolic effect of LGI foods on daylong glucose control acutely and in the long term following a 5-week GI intervention diet in free-living subjects. In this randomised, parallel trial, two groups of nineteen overweight subjects followed an ad libitum 5-week intervention diet in which usual starch was replaced by either LGI or high GI (HGI) starch. During the exploration days (days 1 and 36), subjects ate their assigned DC-labelled test breakfast (LGI or HGI), and total and exogenous glucose kinetics (using stable isotopes), postprandial concentrations of glucose, insulin, lipid profile and nutrient oxidation were assessed after the test breakfast and a standardised lunch. At day I. LGI breakfast significantly decreased post-breakfast glycaemic response with a parallel decrease in exogenous and total glucose appearance (P