Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence
Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence
复制标题
DOI：
10.1002/ajmg.b.30132
复制
发表时间：
2005-02-05
影响因子：
2.8
通讯作者：
Kranzler, HR
中科院分区：
文献类型：
--
作者：
Feinn, R;Nellissery, M;Kranzler, HR
神经递质5-羟色胺（5-HT）已被证明可以调节动物和人类的酒精消耗。由于5-羟色胺转运蛋白（5-HTT）的活性调节5-羟色胺水平，编码该蛋白的基因可能与酒精依赖（AD）的风险有关。关于5-HTTLPR启动子区域（5-HTTLPR）功能性插入-删除多态性与AD关联的研究得出了不一致的结果。我们对17项已发表的研究（包括3489名酗酒者和2325名对照者）的数据进行了荟萃分析，调查了5-HTTLPR等位基因与AD之间的关系。5-HTTLPR短等位基因(S)的频率与AD显著相关[比值比(OR) = 1.18, 95% CI = 1.03-1.33]。此外，伴有精神疾病或早发性或更严重AD亚型的AD患者与S等位基因的关联更大[or = 1.34 (95% CI=1.11-1.63)]。5-HTTLPR的等位基因变异会增加AD的风险，在具有共同临床特征的个体中观察到的影响最大。(C) 2005 Wiley-Liss, Inc。
The neurotransmitter serotonin (5-HT) has been shown to regulate alcohol consumption in both animals and humans. Since activity of the 5-HT transporter protein (5-HTT) regulates 5-HT levels, the gene encoding this protein may contribute to the risk of alcohol dependence (AD). Studies of the association to AD of a functional insertion-deletion polymorphism in the 5-HTT-linked promoter region (5-HTTLPR) have yielded inconsistent results. We conducted a meta-analysis of data from 17 published studies (including 3,489 alcoholics and 2,325 controls) investigating the association between 5-HTTLPR alleles and AD. The frequency of the short (S) allele at 5-HTTLPR was significantly associated with AD [odds ratio (OR) = 1.18, 95% CI = 1.03-1.33). Moreover, a greater association with the S allele was seen among individuals with AD complicated by either a co-morbid psychiatric condition or an early-onset or more severe AD subtype [OR= 1.34 (95% CI=1.11-1.63)]. Allelic variation at 5-HTTLPR contributes to risk for AD, with the greatest effect observed among individuals with a co-occurring clinical feature. (C) 2005 Wiley-Liss, Inc.