T cells that promote B-Cell maturation in systemic autoimmunity.
T cells that promote B-Cell maturation in systemic autoimmunity.
复制标题
促进全身自身免疫性B细胞成熟的T细胞。
DOI：
10.1111/j.1600-065x.2012.01122.x
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发表时间：
2012-05
影响因子：
8.7
通讯作者：
Craft J
中科院分区：
文献类型：
--
作者：
Weinstein JS;Hernandez SG;Craft J
滤泡辅助性T（Tfh）细胞在帮助B细胞在遇到病原体时产生抗体方面发挥重要作用。这种T细胞帮助典型地发生在位于次级淋巴器官的B细胞滤泡中的生发中心（GC），这是免疫球蛋白亲和力成熟和同种型转换的位点。B细胞成熟也发生在滤泡外，在脾的红髓和淋巴结的髓索中，伴随浆细胞形成和抗体产生。T细胞依赖性免疫应答中滤泡外病灶（EF）的形成依赖于具有Tfh细胞特征的CD4+ T细胞。致病性自身抗体是由自身反应性B细胞在GC和EF中经历了亲和选择和类别转换的体细胞超突变而产生的，是全身性自身免疫中终末器官损伤的主要贡献者。在系统性自身免疫性疾病中，成熟的B细胞产生自身抗体，就像正常免疫反应中的抗体一样，在很大程度上需要T辅助细胞。这篇综述强调了Tfh细胞的发展，作为对具有相似特征的人Tfh细胞和血源性细胞的更深入讨论的介绍，以及这些细胞在促进全身性自身免疫中的作用。
Follicular helper T (Tfh) cells play an essential role in helping B cells generate antibodies upon pathogen encounters. Such T-cell help classically occurs in germinal centers (GCs) located in B-cell follicles of secondary lymphoid organs, a site of immunoglobulin affinity maturation and isotype switching. B-cell maturation also occurs extrafollicularly, in the red pulp of the spleen and medullary cords in lymph nodes, with plasma cell formation and antibody production. Development of extrafollicular foci (EF) in T-cell-dependent (TD) immune responses is reliant upon CD4+ T cells with characteristics of Tfh cells. Pathogenic autoantibodies, arising from self-reactive B cells having undergone somatic hypermutation with affinity selection and class switching within GCs and EF, are major contributors to the end-organ injury in systemic autoimmunity. B cells maturing to produce autoantibodies in systemic autoimmune diseases, like those in normal immune responses, largely require T-helper cells. This review highlights Tfh cell development as an introduction to a more in-depth discussion of human Tfh cells and blood borne cells with similar features and the role of these cells in promotion of systemic autoimmunity.