TRANSMISSIBLE GASTROENTERITIS
TRANSMISSIBLE GASTROENTERITIS
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DOI：
10.1136/vr.122.19.462
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发表时间：
1988-05-07
影响因子：
2.2
通讯作者：
GARWES, DJ
中科院分区：
文献类型：
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作者：
GARWES, DJ
传染性胃肠炎（TGE）病毒是一种冠状病毒，可引起猪小肠急性感染。这种疾病在成年动物中很少致命，但在新生儿中可引起广泛死亡。自从20世纪50年代在英国首次发现这种疾病以来，这种疾病一直是动物流行病，但最近它已在一些农场建立起来，在过去两年中，一种与抗原性相关的呼吸道病毒已成为全国牛群的地方病。仔猪对TGE的免疫依赖于牛奶的被动保护，这是不可能通过疫苗实现的，研究旨在了解病毒与猪之间相互作用的本质。怀孕母猪感染后，产生抗体的细胞迁移到乳腺，在那里它们将病毒中和抗体分泌到乳汁中；未来的疫苗需要激发类似的反应。与中和相关的病毒颗粒上抗原位点的位置和数量已经用单克隆抗体确定，其他病毒基因在发病机制和免疫中的作用正在用基因工程技术研究。
Transmissible gastroenteritis (TGE) virus, a coronavirus, causes an acute infection of the small intestine of the pig. The disease is rarely fatal in adult animals but can cause extensive mortality in the neonate. Since its first description in Britain in the 1950s, the disease has been epizootic but recently it has become established on some farms and an antigenically related respiratory virus has become endemic in the national herd over the past two years. Piglet immunity to TGE, which relies on passive protection from milk, has been impossible to achieve with vaccines and research has aimed at understanding the nature of the interaction between virus and the pig. Following infection of the pregnant sow, antibody-producing cells migrate to the mammary gland where they secrete virus neutralising antibodies into the milk; prospective vaccines will need to stimulate a similar response. The location and number of antigenic sites on the virus particle associated with neutralisation have been established with monoclonal antibodies and the role of the other viral genes in pathogenesis and immunity is being studied with genetic engineering techniques.