How Schizophrenia Develops: Cognitive and Brain Mechanisms Underlying Onset of Psychosis.
How Schizophrenia Develops: Cognitive and Brain Mechanisms Underlying Onset of Psychosis.
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DOI：
10.1016/j.tics.2015.09.009
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发表时间：
2015-12
影响因子：
19.9
通讯作者：
Cannon TD
中科院分区：
文献类型：
--
作者：
Cannon TD
识别精神分裂症发展的认知和神经机制需要在发病前对个体进行纵向观察。在这里，最近的研究前驱个体谁进展到完全精神病简要回顾与精神分裂症病理生理模型。总之，这些工作表明，大脑连接的中断，主要是由皮层锥体神经元上树突棘的逐渐减少所驱动的，可能是一个关键的触发机制。最早的中断出现在涉及根据时间、地点和代理引用经验的电路中，这可能导致无法识别特定的认知是自我产生的，或者限制基于先前经验的事件意义的解释，为错误的现实测试提供脚手架。
Identifying cognitive and neural mechanisms involved in the development of schizophrenia requires longitudinal observation of individuals prior to onset. Here recent studies of prodromal individuals who progress to full psychosis are briefly reviewed in relation to models of schizophrenia pathophysiology. Together, this body of work suggests that disruption in brain connectivity, driven primarily by a progressive reduction in dendritic spines on cortical pyramidal neurons, may represent a key triggering mechanism. The earliest disruptions appear to be in circuits involved in referencing experiences according to time, place, and agency, which may result in a failure to recognize particular cognitions as self-generated or to constrain interpretations of the meaning of events based on prior experiences, providing the scaffolding for faulty reality testing.