Association between a satellite DNA sequence and the Responder of Segregation Distorter in D. melanogaster.
Association between a satellite DNA sequence and the Responder of Segregation Distorter in D. melanogaster.
复制标题
黑腹果蝇中卫星 DNA 序列与分离扭曲响应者之间的关联。
DOI：
10.1016/0092-8674(88)90550-8
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发表时间：
1988
期刊：
影响因子：
64.5
通讯作者：
Lin,GF
中科院分区：
文献类型：
--
作者：
Wu,CI;Lyttle,TW;Wu,ML;Lin,GF
大量的卫星DNA序列总是与响应者(f？sp) D. melanogaster中偏析扭曲因子。在适当的遗传背景下，Rsp在精子发生过程中引起异常的染色质凝聚，导致携带Rsp的精子功能障碍和减数分裂驱动。每当Rsp发生突变时，重复序列就会被删除或转移到Y染色体上。此外，部分Rsp向Y的易位与不完全重复序列的易位有关。在35条独立衍生的染色体中，重复次数与对畸变的敏感性几乎完全相关。我们假设这个卫星重复阵列代表响应者本身。最后，这个基因座的分子结构是非常多变的，表明一个非常活跃的变化过程。
A large array of satellite DNA sequences are always associated with the Responder (f? sp) element of Segregation Distorter in D. melanogaster. In the appropriate genetic backgrounds, Rsp causes aberrant chromatin condensation in spermiogenesis, leading to dysfunction of sperm carrying Rsp, and meiotic drive. The repeat array Is deleted or translocated to the Y chromosome whenever Rsp is. Moreover, the translocation of part of Rsp to Y is associated with the translocation of an incomplete repeat array. The number of repeats among 35 independently derived chromosomes correlates nearly perfectly with sensitivity to distortion. We hypothesize that this satellite repeat array represents Responder itself. Finally, the molecular structure of this locus is extremely variable, indicating a very active process of change.