Resting-State Retinotopic Organization in the Absence of Retinal Input and Visual Experience
Resting-State Retinotopic Organization in the Absence of Retinal Input and Visual Experience
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DOI：
10.1523/jneurosci.4715-14.2015
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发表时间：
2015-09-09
影响因子：
5.3
通讯作者：
Fine, Ione
中科院分区：
文献类型：
--
作者：
Bock, Andrew S.;Binda, Paola;Fine, Ione
早期视觉区域具有神经元接受野，形成视觉空间的采样马赛克，从而产生一系列视网膜定位图，其中相同的空间区域在多个视觉区域中表示。目前尚不清楚这种视网膜组织的发展和维持在多大程度上依赖于视网膜波和/或视觉经验。我们检查了正常视力、早期失明和无眼（双眼发育不全）个体静息状态BOLD数据的皮质-皮质感受野组织，发现V1和V2/V3之间的静息状态相关性在所有受试者组中都是视网膜原位组织的。这些结果表明，V1-V3之间静息状态连接的总体视网膜病变模式既不需要视网膜波也不需要视觉经验来发展并持续到成年期。
Early visual areas have neuronal receptive fields that form a sampling mosaic of visual space, resulting in a series of retinotopic maps in which the same region of space is represented in multiple visual areas. It is not clear to what extent the development and maintenance of this retinotopic organization in humans depend on retinal waves and/or visual experience. We examined the corticocortical receptive field organization of resting-state BOLD data in normally sighted, early blind, and anophthalmic (in which both eyes fail to develop) individuals and found that resting-state correlations between V1 and V2/V3 were retinotopically organized for all subject groups. These results show that the gross retinotopic pattern of resting-state connectivity across V1-V3 requires neither retinal waves nor visual experience to develop and persist into adulthood.