An Experimental Study on the Behavior of Merkel Cells under a Denture Base
An Experimental Study on the Behavior of Merkel Cells under a Denture Base
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义齿基托下默克尔细胞行为的实验研究
DOI：
10.2186/prp.2.59
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Takashi Inoue
中科院分区：
文献类型：
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作者：
Ken Ishizaki;K. Sakurai;Y. Tazaki;M. Tazaki;M. Shimono;Yuta Suzuki;K. Matsuzaka;Takashi Inoue
用途：本研究旨在探讨默克尔细胞在义齿基托持续压力作用下的行为。材料与方法：将4-Meta/MMA-TBB粘接树脂制成的义齿基托贴于金黄地鼠腭皱上，2周和3周后处死动物。免疫组化结果显示对照组的皱褶顶端可见CK 20阳性细胞聚集。然而，CK 20阳性细胞在各时间段的实验组中观察到显著减少。结论：这些结果表明，默克尔细胞在持续压力下发生凋亡，感觉系统可能发生了变化。
Purpose : The purpose of this study was to investigate Merkel cell behavior under the condition of continuous pressure by a denture base.Materials and Methods : A denture base made of 4-META/MMA-TBB adhesive resin was applied on the palatal rugae of golden hamsters, and the animals were sacrificed 2 and 3 weeks later.Results : Immunohistochemically, an aggregation of CK 20-positive cells was seen at the tip of the rugae in the control groups. However, a significant decrease in CK 20-positive cells was observed in the experimental groups at each of the time periods.Conclusion : These results suggest that the Merkel cells became apoptotic under continuous pressure and that the sensory system might have changed.