The overlapping roles of antimicrobial peptides and complement in recruitment and activation of tumor-associated inflammatory cells.
The overlapping roles of antimicrobial peptides and complement in recruitment and activation of tumor-associated inflammatory cells.
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DOI：
10.3389/fimmu.2015.00002
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发表时间：
2015
影响因子：
7.3
通讯作者：
Sanyi RH
中科院分区：
文献类型：
--
作者：
Al-Rayahi IA;Sanyi RH
抗菌肽（Antimicrobial Peptides，AMP）是由植物、哺乳动物和微生物产生的一组具有生物活性的小分子（6-100个氨基酸）。AMP是先天性免疫反应的重要成分，具有有效的抗生素、抗真菌和抗病毒活性。此外，AMP可能参与许多其他过程，如血管生成和免疫应答的调节，如刺激趋化因子和白细胞的趋化性。AMP已被提议作为传染病的替代疗法。AMP还可以对肿瘤细胞发挥细胞毒活性。进一步了解这些肽在肿瘤发生和发展过程中的生物学功能，可能有助于开发新的抗肿瘤疗法，并精确应用先天分子。AMP和补体在塑造微环境中发挥不同的作用（表1）。补体系统的组分是响应感染和无菌炎症的组成部分。此外，补体在肿瘤微环境中的细胞运输中起作用，从而可能在对癌症的免疫应答中起作用。本文将试图概述AMP和补体在肿瘤微环境中动员和募集细胞的特点。
Antimicrobial peptides (AMPs) represent a group of small (6–100 amino acids), biologically active molecules, which are produced by plants, mammals, and microorganisms. An important element of the innate immune response, AMP, possesses potent antibiotic, antifungal, and antiviral activities. Furthermore, AMP may be involved in a number of other processes such as angiogenesis and modulation of the immune response such as stimulation of chemokines and chemotaxis of leukocytes. AMPs have been proposed as alternative therapies for infectious diseases. AMP may also exert cytotoxic activity against tumor cells. Further understanding of the biological function of these peptides during tumor development and progression may aid in the development of novel anti-tumor therapies with refined application of innate molecules. AMP and complement have distinct roles to play in shaping the microenvironment (Table 1). Components of the complement system are integral contributors in responding to infection and sterile inflammation. Moreover, complement plays a role in the trafficking of cells in the tumor microenvironment, and thereby possibly in the immune response to cancer. This article will try to outline characteristics of AMP and complement in mobilization and recruitment of cells in tumor microenvironment.