Male rats with inherited insensitivity to androgen show reduced sexual behavior.
Male rats with inherited insensitivity to androgen show reduced sexual behavior.
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遗传性对雄激素不敏感的雄性大鼠表现出性行为减少。
DOI：
10.1210/endo-100-1-197
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发表时间：
1977
期刊：
影响因子：
4.8
通讯作者：
M. Buehler
中科院分区：
文献类型：
--
作者：
F. A. Beach;M. Buehler
假雌雄同体斯坦利Gumbreck雄性大鼠表现出不频繁和不完整的交配反应，接受女性。丙酸睾酮的管理没有增加这种行为。注射雌二醇和孕酮诱导pseudohermaphrodites表现出脊柱前凸时，安装的刺激男性，但女性的反应并不比正常男性给予相同的激素治疗。这一假说表明，在发育早期产生足够的内源性睾丸激素，导致女性行为机制对雌二醇的正常脱敏，但男性行为机制通常对睾酮不敏感。
Pseudohermaphroditic Stanley-Gumbreck male rats showed infrequent and incomplete copulatory responses to receptive females. Administration of testosterone propionate produced no increase in this behavior. Injections of estradiol and progesterone induced the pseudohermaphrodites to exhibit lordosis when mounted by stimulus males, but feminine responses were no more frequent than those of normal males given the same hormonal treatment. The hypothesis is suggested that early in development sufficient endogenous testis hormone is produced to cause normal desensitization of feminine behavioral mechanisms to estradiol, but that mechanisms for male behavior are not normally sensitized to testosterone.