Dopaminergic suppression of angiotensin II-induced aldosterone secretion in man: differential responses during sodium loading and depletion.
Dopaminergic suppression of angiotensin II-induced aldosterone secretion in man: differential responses during sodium loading and depletion.
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多巴胺能抑制血管紧张素 II 诱导的人体醛固酮分泌：钠负荷和耗竭期间的差异反应。
DOI：
10.1016/0026-0495(84)90207-5
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
R. Carey
中科院分区：
文献类型：
--
作者：
C. Drake;N. Ragsdale;D. Kaiser;R. Carey
先前的研究表明，人体内的醛固酮分泌可能受到多巴胺能机制的抑制。多巴胺不抑制醛固酮对血管紧张素II的反应。由于钠缺乏与肾脏多巴胺形成减少有关，我们研究了多巴胺在钠缺乏状态下对血管紧张素ii诱导的醛固酮分泌的影响。6名正常受试者在钠摄入量为10 mEq （UNaV 17±2 mEq 24小时）时保持平衡，连续两天给予多巴胺4 μg/kg/min或载药210分钟。多巴胺或载体输注60分钟后，受试者连续输注血管紧张素II 30分钟，剂量分别为0.5、1、2、4和6皮莫尔/kg/min。对照血浆醛固酮浓度分别为15±3（平均1±SE）和25±3 ng/dL。血管紧张素II剂量为4和6 picomol/kg/min时，醛固酮对血管紧张素II的反应大于多巴胺（P< 0.025）。载药组血管紧张素-醛固酮剂量反应曲线斜率（0.33）大于多巴胺组（0.16），P< 0.01。注射120 min后，多巴胺组血清催乳素浓度（1.6±0.8 ng/mL）低于对照组（6.4±1.2 ng/mL， P< 0.05），且在注射剩余时间内仍保持抑制作用。血管紧张素II剂量为2、4和6 picomol/kg/min时，载药组舒张压高于多巴胺组（P< 0.05）。多巴胺给药与注射90 ~ 150分钟血浆皮质醇浓度升高相关（P< 0.05）。同样的6名受试者在300 mEq钠摄入量（UNaV 287±18 mEq 24小时）平衡时，醛固酮反应或血管紧张素ii -醛固酮剂量-反应曲线斜率与多巴胺或对照剂没有差异。注射90分钟后，多巴胺组血清催乳素浓度（5.4±1.2 ng/mL）低于对照组（9.3±1.4 ng/mL， P< 0.05），且在实验结束后仍保持抑制状态。注射120 ~ 150 min时，多巴胺组大鼠皮质醇水平显著高于对照组（P< 0.05）。综上所述，多巴胺抑制血管紧张素ii刺激的醛固酮分泌。
Previous studies have shown that aldosterone secretion may be inhibited by dopaminergic mechanisms in man. Dopamine does not inhibit aldosterone responses to angiotensin II in sodium-replete normal subjects. Since sodium deficiency is associated with a reduction in renal dopamine formation, we investigated the effect of dopamine on angiotensin II-induced aldosterone secretion in the sodium-depleted state. Six normal subjects in balance at 10 mEq sodium intake (UNaV 17±2 meq 24 hr) received dopamine 4 μg/kg/min or vehicle for 210 minutes on two consecutive days. After 60 minutes of the dopamine or vehicle infusion, the subjects received successive 30-minute infusions of angiotensin II in increasing doses of 0.5, 1, 2, 4 and 6 picomol/kg/min. Control plasma aldosterone concentrations before vehicle or dopamine were 15±3 (mean 1±SE) and 25±3 ng/dL, respectively. Aldosterone responses to angiotensin II were greater with vehicle than dopamine at angiotensin II doses of 4 and 6 picomol/kg/min (P< 0.025). The slope of angiotensin-aldosterone dose-response curve was steeper with vehicle (0.33) than with dopamine (0.16), P< 0.01. Serum prolactin concentrations were lower with dopamine (1.6±0.8 ng/mL) than with vehicle (6.4±1.2 ng/mL, P< 0.05) by 120 minutes of infusion and remained suppressed with dopamine for the remainder of the dopamine infusion. Diastolic blood pressure was higher (P< 0.05) with vehicle than with dopamine at angiotensin II doses of 2, 4, and 6 picomol/kg/min. Dopamine administration was associated with an increase in plasma cortisol concentration from 90 to 150 minutes of infusion (P< 0.05). The same six subjects in balance at 300 mEq sodium intake (UNaV 287±18 meq 24 hr) had no difference in aldosterone response or slope of the angiotensin II-aldosterone dose-response curve with dopamine or vehicle. Serum prolactin concentrations were lower with dopamine (5.4±1.2 ng/mL) than with vehicle (9.3±1.4 ng/mL, P< 0.05) by 90 minutes of infusion and remained suppressed for the rest of the study. Cortisol levels were significantly higher with dopamine than with vehicle from 120 to 150 minutes of infusion (P< 0.05). In conclusion, dopamine inhibits angiotensin II-stimulated aldosterone secretion during sodium deficiency in man.
随着钠摄入量的变化，多巴胺能调节醛固酮对血管紧张素 II 的反应。
DOI：
10.1210/jcem-56-2-340
发表时间：
1983
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Gordon,MB;Moore,TJ;Dluhy,RG;Williams,GH
通讯作者：
Williams,GH
甲氧氯普胺对人类醛固酮分泌的刺激：肾脏和垂体介导的明显独立性。
DOI：
10.1016/0026-0495(81)90161-x
发表时间：
1981
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Pratt,JH;Ganguly,A;Parkinson,CA;Weinberger,MH
通讯作者：
Weinberger,MH