Brain morphological alternation in chronic pain patients with neuropathic characteristics.
Brain morphological alternation in chronic pain patients with neuropathic characteristics.
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DOI：
10.1177/1744806916652408
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发表时间：
2016
期刊：
影响因子：
3.3
通讯作者：
Saito S
中科院分区：
文献类型：
--
作者：
Sugimine S;Ogino Y;Kawamichi H;Obata H;Saito S
神经病理特征在生理和心理上高度参与慢性疼痛的发展。然而，很少有人知道神经病理特征和脑形态学改变之间的关系。本研究的目的是通过对慢性疼痛患者进行基于体素的形态计量学研究来探讨慢性疼痛发展的机制。首先，我们使用painDETECT问卷对12名慢性疼痛患者的神经病理学特征进行了评估。其次，为了通过基于体素的形态测量来评估灰质体积的变化，我们对大脑进行了磁共振成像。我们应用多元回归分析这两种评估方法。painDETECT问卷评分与双侧前扣带回和右侧后扣带回灰质体积呈显著正相关。我们的研究结果表明，神经病理学特征强烈影响慢性疼痛患者与疼痛调制相关的大脑区域，因此，有助于慢性疼痛的严重程度。
Neuropathic characteristics are highly involved in the development of chronic pain both physically and psychologically. However, little is known about the relationship between neuropathic characteristics and brain morphological alteration. The aim of this study is to investigate the mechanisms of chronic pain development by examining the above-mentioned relationships by voxel-based morphometry in patients with chronic pain. First, we assessed neuropathic characteristics using the painDETECT Questionnaire in 12 chronic pain patients. Second, to assess the gray matter volume changes by voxel-based morphometry, we conducted magnetic resonance imaging of the brain. We applied multiregression analysis of these two assessment methods. There were significant positive correlations between painDETECT Questionnaire scores and the gray matter volume in the bilateral anterior cingulate cortex and right posterior cingulate cortex. Our findings suggest that neuropathic characteristics strongly affect the brain regions related to modulation of pain in patients with chronic pain and, therefore, contribute to the severity of chronic pain.