Recovery of resting brain connectivity ensuing mild traumatic brain injury.
Recovery of resting brain connectivity ensuing mild traumatic brain injury.
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DOI：
10.3389/fnhum.2015.00513
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发表时间：
2015
影响因子：
2.9
通讯作者：
Biswal BB
中科院分区：
文献类型：
--
作者：
Bharath RD;Munivenkatappa A;Gohel S;Panda R;Saini J;Rajeswaran J;Shukla D;Bhagavatula ID;Biswal BB
大脑在从损伤中恢复时显示出增强的可塑性。我们的目的是确定从轻度创伤性脑损伤（mTBI）中恢复的患者的时间依赖性可塑性变化。25例轻度颅脑损伤受试者在36 h、3个月和6个月内使用静息状态功能连接（RSFC）进行纵向评估。在p <0.005处分析患者组内以及与健康对照组相比的基于感兴趣区域（ROI）的连接性随时间的差异。我们发现了33个不同的ROI对，揭示了它们的连接强度随时间的显着变化。在3个月内，mTBI人群中大多数ROI对的连接性降低，在6个月时增加并与健康对照相当。在前3个月这种弥漫性的连接性下降中，也有少数地区的连接性增加。这种超连接性在36小时内涉及显著性网络和默认模式网络，在3个月时涉及舌，下额叶和额顶叶网络。我们在6个月恢复窗口期间评估的相当同质的mTBI患者组中的发现定义了随着大脑从损伤中恢复而随时间变化的大脑连接变化。这些变化大多发生在受伤后3至6个月的额叶和顶叶。几个网络的超连通性支持了前6个月的正常恢复，这是否可以预测大脑功能的早期和有效恢复还有待于在未来的研究中观察。
Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.