In vivo and in vitro genotoxicity of selected compounds toward rodent pancreas.
In vivo and in vitro genotoxicity of selected compounds toward rodent pancreas.
复制标题
所选化合物对啮齿动物胰腺的体内和体外遗传毒性。
DOI：
10.1093/carcin/8.8.1033
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发表时间：
1987
期刊：
影响因子：
4.7
通讯作者：
Longnecker,DS
中科院分区：
文献类型：
--
作者：
Curphey,TJ;Coon,CI;Schaeffer,BK;Longnecker,DS
采用碱性洗脱分析技术，检查了11种已知或疑似胰腺致癌物在给予大鼠和仓鼠时损伤胰腺腺泡细胞DNA的能力。这两个物种对几种药剂的反应不同。在选定的情况下，还在体外暴露于试剂的培养的胰腺腺泡细胞中评估DNA损伤。体内和体外产生的DNA损伤的比较提供了胰腺代谢在激活胰腺致癌物中的作用的有用信息。最后，获得了与胰腺癌起源细胞问题密切相关的信息。
Using the technique of alkaline elution analysis, the ability of 11 known or suspected pancreatic carcinogens to damage the DNA of pancreatic acinar cells when administered to rats and hamsters was examined. The two species respond differently to several agents. In selected instances, DNA damage was also assessed in cultured pancreatic acinar cells exposedin vitroto the agents. Comparisons of DNA damage producedin vivowith that producedin vitrogave useful information on the role of pancreatic metabolism in activating pancreatic carcinogens. Finally, information germane to the question of the cell of origin for pancreatic cancer was obtained.