An association of serum ALT with elevated blood pressure in senior adults: a case-control study
An association of serum ALT with elevated blood pressure in senior adults: a case-control study
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DOI：
10.1080/10641963.2016.1200608
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发表时间：
2016-01-01
影响因子：
12.3
通讯作者：
Zhang, Na
中科院分区：
文献类型：
--
作者：
Hong, Xiuqin;Wongtongkam, Nualnong;Zhang, Na
高血压是中国心血管疾病的主要危险因素；因此，确定良好的血清标记物可能在降低发病率方面提供成本效益。在这项以人群为基础的病例对照研究中，参与者从湖南省的五个区招募，416例病例与相同数量的对照组相匹配。评估与血压升高相关的标志物：体重指数、总胆固醇、甘油三酯、空腹血糖和肌酐。三种潜在的血清标志物同型半胱氨酸（HCY）、c反应蛋白（CRP）和丙氨酸转氨酶（ALT）被分为正常和高水平。采用二元逻辑回归确定优势比（ORs）和95%置信区间（ci）。结果表明，ALT是预测高血压高风险的有效血清标志物，OR = 2.94, 95% CI(1.44-6.02)，而HCY和CRP在病例与对照组之间无显著差异。此外，高浓度的HCY似乎可能对血压升高具有保护作用。经性别调整后，女性高血压患者的OR是男性高血压患者的近5倍（OR = 4.34, 95% CI = 1.17-16.04）。该研究强烈支持ALT是高血压患者的潜在指标的发现。
Hypertension is a major risk factor for cardiovascular diseases in China; hence, identifying good serum markers might provide cost benefits in terms of reducing morbidity rates. In this population-based case-control study, participants were recruited from five districts in Hunan province, and 416 cases were matched with an equal number of controls. Markers related to elevated blood pressure were assessed: Body Mass Index, total cholesterol, triglycerides, fasting blood glucose, and creatinine. Three potential serum markers homocysteine (HCY), C-reactive protein (CRP), and alanine aminotransferase (ALT) were dichotomized as normal or high level. Binary logistic regression was used to determine odds ratios (ORs) and 95% confidence intervals (CIs). The findings showed that ALT is a powerful serum marker for predicting high risk of high blood pressure with OR = 2.94, 95% CI (1.44-6.02), while there were no significant differences between cases and controls for HCY and CRP. Additionally, it seems likely that high concentrations of HCY conferred a protective effect against elevated blood pressure. When adjusted for sex, ORs for hypertensive females were nearly five times higher than for hypertensive males (OR = 4.34, 95% CI = 1.17-16.04). The study strongly supports findings showing ALT is a potential indicator for patients with hypertension.