MP2RAGE Multiple Sclerosis Magnetic Resonance Imaging at 3 T
MP2RAGE Multiple Sclerosis Magnetic Resonance Imaging at 3 T
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DOI：
10.1097/rli.0b013e31824600e9
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发表时间：
2012-06-01
影响因子：
6.7
通讯作者：
Krueger, Gunnar
中科院分区：
文献类型：
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作者：
Kober, Tobias;Granziera, Cristina;Krueger, Gunnar
目的：多发性硬化症(MS)的病变检测和定性是其临床诊断的重要组成部分，也是一个重要的研究领域。在这项初步研究中，我们将最近引入的两种反转对比磁化准备快速梯度回波序列(MP2RAGE)应用于早期MS患者。材料和方法：MP2RAGE是一种三维(3D)磁化准备的快速梯度回波导数，提供均匀的T1加权和同时的T1标测。MP2RAGE的性能与2种临床常规序列(2D液体衰减反转恢复[FLAIR]和3D磁化准备的快速梯度回波[MP-RAGE])和2种最先进的临床研究序列(3DFLAIR-SPACE[使用不同翻转角度进化的应用优化对比的采样完美性]、流体衰减可变翻转角度快速自旋回波技术和3D双重反转恢复空间)的性能进行了比较。在获得当地机构审查委员会的批准后，纳入了10名早期女性MS患者(年龄31.6+/-4.7岁；病程3.8+/-1.9年；扩展残疾状况量表评分中位数1.75)和10名年龄和性别匹配的对照组。在所有5种对比中，多发性硬化症病变由两名经验丰富的医生识别并分配给脑部位置和组织类型。结果与结论：3D T1加权高分辨率MP2RAGE增强扫描为MS病变的评估提供了一种敏感的手段。MP2RAGE获得的额外的定量T1弛豫时间图提供了进一步的潜在诊断和预后信息，可以帮助(A)更好地区分病变亚型和(B)分期和预测MS的活动和演变。结果还表明，T2加权双反转恢复和FLAIR空间对比是MP2RAGE在病变检测方面有吸引力的补充。
Objectives: Lesion detection and characterization in multiple sclerosis (MS) are an essential part of its clinical diagnosis and an important research field. In this pilot study, we applied the recently introduced two inversion-contrast magnetization-prepared rapid gradient echo sequence (MP2RAGE) to patients with early-stage MS.Materials and Methods: The MP2RAGE is a 3-dimensional (3D) magnetization-prepared rapid gradient echo derivative providing homogeneous T1 weighting and simultaneous T1 mapping. The MP2RAGE performance was compared with that of 2 clinical routine sequences (2D fluid-attenuated inversion recovery [FLAIR] and 3D magnetization-prepared rapid gradient echo [MP-RAGE]) and 2 state-of-the art clinical research sequences (the 3DFLAIR-SPACE [sampling perfection with application-optimized contrasts by using different flip-angle evolutions], a fluid-attenuated variable flip-angle fast spin echo technique, and the 3D double-inversion recovery SPACE). A cohort of 10 early-stage female MS patients (age, 31.6 +/- 4.7 years; disease duration, 3.8 +/- 1.9 years; median expanded disability status scale score, 1.75) and 10 age-and gender-matched controls were enrolled after approval of the local institutional review board was obtained. Multiple sclerosis lesions were identified and assigned to brain locations and tissue types by two experienced physicians in all 5 contrasts. Subsequently, lesions were manually delineated for comparison and statistical analysis of lesion count, volume and quantitative measures.Results and Conclusions: The results show that the 3D T1-weighted high-resolution MP2RAGE contrast provides a sensitive means for MS lesion assessment. The additional quantitative T1 relaxation time maps obtained with the MP2RAGE provide further potential diagnostic and prognostic information that could help (a) to better discriminate lesion subtypes and (b) to stage and predict the activity and the evolution of MS. Results also indicate that the T2-weighted double-inversion recovery and FLAIR-SPACE contrasts are attractive complements to the MP2RAGE for lesion detection.