Genetic variants within the cancer susceptibility region 8q24 and ovarian cancer risk in Han Chinese women.
Genetic variants within the cancer susceptibility region 8q24 and ovarian cancer risk in Han Chinese women.
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中国汉族女性癌症易感区8q24内的遗传变异与卵巢癌风险
DOI：
10.18632/oncotarget.16861
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发表时间：
2017-05-30
期刊：
影响因子：
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通讯作者：
Li D
中科院分区：
文献类型：
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作者：
Han J;Zhou J;Yuan H;Zhu L;Ma H;Hang D;Li D
越来越多的证据表明，8q24染色体上的遗传变异赋予了对各种癌症的易感性。本病例对照研究旨在探讨8q24基因变异与中国汉族女性卵巢癌风险之间的关系。采用TaqMan等位基因鉴别法，对377例卵巢癌患者和1034例无癌对照进行了rs13281615 A > G和rs6983267 T > G基因分型。Logistic回归分析显示，rs6983267基因G等位基因与卵巢癌发病风险增加显著相关（加性模型：校正OR = 1.21, 95% CI = 1.01 ~ 1.43, P = 0.048；隐性模型：校正OR = 1.51, 95% CI = 1.06 ~ 2.15, P = 0.023）。然而，rs13281615与卵巢癌之间没有明显的关联。在分层分析中，rs6983267变异的风险效应在绝经前妇女中仍然显著（加性模型：校正OR = 1.62, 95% CI = 1.18-2.23, P = 0.003）。综上所述，本研究提示8q24 rs6983267可能参与了绝经前汉族女性卵巢癌的易感性，支持8q24的多效性在癌变中的作用。
Accumulating evidence suggests that genetic variants at chromosome 8q24 confer susceptibility to various types of cancer. This case-control study was designed to explore the relationship between genetic variants at 8q24 and ovarian cancer risk in Han Chinese women. Two variants (rs13281615 A > G and rs6983267 T > G) were genotyped in 377 ovarian cancer cases and 1034 cancer-free controls using TaqMan allelic discrimination assay. Logistic regression analysis revealed that the G allele of rs6983267 was significantly associated with increased risk of ovarian cancer (additive model: adjusted OR = 1.21, 95% CI = 1.01–1.43, P = 0.048; recessive model: adjusted OR = 1.51, 95% CI = 1.06–2.15, P = 0.023). However, no significant association was observed between rs13281615 and ovarian cancer. In stratified analysis, the risk effect of rs6983267 variant remained significant in premenopausal women (additive model: adjusted OR = 1.62, 95% CI = 1.18–2.23, P = 0.003). Summarily, this study suggested that 8q24 rs6983267 may contribute to the susceptibility of ovarian cancer in premenopausal Han Chinese women, supporting the pleiotropy of 8q24 in carcinogenesis.