Subthalamic local field potentials in Parkinson's disease and isolated dystonia: An evaluation of potential biomarkers.
Subthalamic local field potentials in Parkinson's disease and isolated dystonia: An evaluation of potential biomarkers.
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DOI：
10.1016/j.nbd.2016.02.015
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发表时间：
2016-05
影响因子：
6.1
通讯作者：
Starr PA
中科院分区：
文献类型：
--
作者：
Wang DD;de Hemptinne C;Miocinovic S;Qasim SE;Miller AM;Ostrem JL;Galifianakis NB;San Luciano M;Starr PA
帕金森氏病（PD）患者丘脑下核记录的局部场电位（LFP）在β (13-30 Hz)频率范围内显示出明显的振荡，左旋多巴和深部脑刺激（DBS）降低β频带频谱功率与运动症状改善相关。β活性的几个特征被认为是帕金森状态的特定生物标志物，尽管这些特征很少在非帕金森条件下进行研究。为了比较PD和孤立性肌张力障碍的静息状态LFP特征并评估疾病特异性生物标志物，我们记录了28例运动刚性PD和12例孤立性肌张力障碍患者在清醒DBS植入期间的丘脑下LFP。分析了谱功率和相幅耦合特性。在26/28 PD和11/12分离的肌张力障碍患者中，LFP功率谱在β频率范围内出现峰值，组间振幅相似。静息状态功率在theta （5-8 Hz）、alpha （8-12 Hz）、beta （13-30 Hz）、宽带gamma （50-200 Hz）或高频振荡（HFO, 250-350 Hz）频段上各组之间没有差异。低频相位与HFO振幅之间的相幅耦合分析显示，在19/28 PD和6/12 PD的肌张力障碍记录中存在显著的相互作用，但在最大耦合或首选相位上无显著差异。丘脑下lfp的两个特征被认为是帕金森病的特异性生物标志物，β功率和β相与HFO振幅的耦合，也存在于孤立性肌张力障碍中，包括局灶性肌张力障碍。这使人们对这些指标作为疾病特异性诊断生物标志物的效用产生了怀疑。
Local field potentials (LFP) recorded from the subthalamic nucleus in patients with Parkinson’s disease (PD) demonstrate prominent oscillations in the beta (13–30 Hz) frequency range, and reduction of beta band spectral power by levodopa and deep brain stimulation (DBS) is correlated with motor symptom improvement. Several features of beta activity have been theorized to be specific biomarkers of the parkinsonian state, though these have rarely been studied in non-parkinsonian conditions. To compare resting state LFP features in PD and isolated dystonia and evaluate disease-specific biomarkers, we recorded subthalamic LFPs from 28 akinetic-rigid PD and 12 isolated dystonia patients during awake DBS implantation. Spectral power and phase-amplitude coupling characteristics were analyzed. In 26/28 PD and 11/12 isolated dystonia patients, the LFP power spectrum had a peak in the beta frequency range, with similar amplitudes between groups. Resting state power did not differ between groups in the theta (5–8 Hz), alpha (8–12 Hz), beta (13–30 Hz), broadband gamma (50–200 Hz), or high frequency oscillation (HFO, 250–350 Hz) bands. Analysis of phase-amplitude coupling between low frequency phase and HFO amplitude revealed significant interactions in 19/28 PD and 6/12 dystonia recordings without significant differences in maximal coupling or preferred phase. Two features of subthalamic LFPs that have been proposed as specific parkinsonian biomarkers, beta power and coupling of beta phase to HFO amplitude, were also present in isolated dystonia, including focal dystonias. This casts doubt on the utility of these metrics as disease-specific diagnostic biomarkers.