Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe
Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe
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DOI：
10.1021/nl051935m
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发表时间：
2006-01-01
期刊：
影响因子：
10.8
通讯作者：
Griffioen, AW
中科院分区：
文献类型：
--
作者：
Mulder, WJM;Koole, R;Griffioen, AW
开发了核磁共振可探测和靶向量子点。为此，量子点被涂上顺磁性和聚乙二醇化的脂质，这导致每个量子点的弛豫率r(1)接近2000 mM(-1)s（-1）。通过共价连接α v/ β 3特异性RGD肽使量子点功能化，并在培养的内皮细胞上评估和证实其特异性。这种纳米探针的双峰特性、高弛豫性和特异性使其成为分子成像的优秀造影剂。
MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alpha v/beta 3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.