Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic.
Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic.
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DOI：
10.1038/srep20385
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发表时间：
2016-02-08
影响因子：
4.6
通讯作者：
Koopmans MP
中科院分区：
文献类型：
--
作者：
Freidl GS;van den Ham HJ;Boni MF;de Bruin E;Koopmans MP
在一般人群和家禽暴露个体中，已报告通过低水平抗体滴度对禽流感（AI）呈血清阳性，这提出了一个问题，即这些发现是否反映了AI的真实感染或交叉反应。在这里，我们调查了血清学概况对人类和禽流感病毒在一般人群中使用蛋白质微阵列平台。我们假设，在最近的H1和H3流感病毒之间较高的抗体多样性将与对旧的大流行和AI病毒的异亚型反应性相关。我们发现抗体谱存在显著异质性。季节性流感病毒抗体多样性的增加与H9和H7的低水平异亚型抗体有关，但与H5禽流感病毒无关。暴露于最近2009年甲型H1N1流感大流行的个体表现出更高的异亚型反应性。我们发现，有一个复杂的相互作用之间的先前暴露于季节性和最近的大流行性流感病毒和发展的异亚型抗体反应性的动物流感病毒。
Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic- and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.