ROLE OF DEEP ABDOMINAL FAT IN THE ASSOCIATION BETWEEN REGIONAL ADIPOSE-TISSUE DISTRIBUTION AND GLUCOSE-TOLERANCE IN OBESE WOMEN
ROLE OF DEEP ABDOMINAL FAT IN THE ASSOCIATION BETWEEN REGIONAL ADIPOSE-TISSUE DISTRIBUTION AND GLUCOSE-TOLERANCE IN OBESE WOMEN
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DOI：
10.2337/diabetes.38.3.304
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发表时间：
1989-03-01
期刊：
影响因子：
7.7
通讯作者：
BOUCHARD, C
中科院分区：
文献类型：
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作者：
DESPRES, JP;NADEAU, A;BOUCHARD, C
应用计算机断层扫描(CT)对52例35.7岁绝经前肥胖妇女的脂肪组织定位与糖耐量的关系进行了研究。5.5年(平均+-SD)，体脂为45.9+-。5.5%。摄入葡萄糖(75g)后，体脂质量和体重指数(BMI)与血糖、胰岛素和连接肽(C-肽)面积显著相关(0.401req)。R.ltoreq。.51，P<；.01)。躯干脂肪堆积和腹部脂肪细胞的大小与葡萄糖后胰岛素水平呈高度显著的相关性。C肽面积与腹部脂肪细胞大小呈正相关(r=0.76，P<；0.01)，与躯干皮褶厚度之和(r=0.59，P<；.001)比与四肢皮褶厚度(r=0.29，P<；0.05)关系更密切。CT测量的皮下和腹深脂肪面积与血浆胰岛素面积有相似的相关性(r分别为0.44和0.49；P<；0.001)，但与糖耐量的相关性显著不同。事实上，腹部皮下脂肪与葡萄糖面积没有显著的相关性，而腹部深层脂肪与葡萄糖面积有显著的相关性(r=.57，P<；.001)。然而，CT测量的大腿中段脂肪沉积与血糖、胰岛素或C肽区域无关。偏相关分析表明，腹脂堆积对糖耐量的影响与总脂肪无关，控制腹脂堆积后，腹脂堆积与糖耐量无相关性。这些结果强调了腹深脂肪作为肥胖女性糖耐量的独立相关因素的重要性。
Computed tomography (CT) was used to study the association between adipose tissue localization and glucose tolerance in a sample of 52 premenopausal obese women aged 35.7 .+-. 5.5 yr (mean .+-. SD) and with a body fat of 45.9 .+-. 5.5%. Body-fat mass and the body mass index (BMI) were significantly correlated with plasma glucose, insulin, and connecting peptide (C-peptide) areas after glucose (75 g) ingestion (.40 .ltoreq. r .ltoreq. .51, P < .01). Trunk-fat accumulation and the size of fat cells in the abdomen displayed highly significant correlations with postglucose insulin levels. The C-peptide area was also positively correlated with abdominal fat cell size (r = .76, P < .01) and was more closely associated with the sum of trunk skin folds (r = .59, P < .001) than with the extremity skin folds (r = .29, P < .05). Subcutaneous and deep-abdomainl-fat areas measured by CT displayed comparable associations with the plasma insulin area (r = .44 and .49, respectively; P < .001) but marked differences in the associations with glucose tolerance. Indeed, subcutaneous abdominal fat was not significantly correlated with the glucose area, whereas deep abdominal fat showed a significant correlation (r = .57, P < .001) with the glucose area. Midthigh fat deposition measured by CT was not, however, correlated with plasma glucose, insulin, or C-peptide areas. Partial correlation analyses indicated that the effect of accumulation of deep abdominal fat on glucose tolerance was independent from total adiposity and that no association was observed between total adiposity and glucose tolerance after control for accumulation of deep abdominal fat. These results emphasize the importance of deep abdominal fat as an independent correlate of glucose toleranace in obese women.