Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy - a pilot study
Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy - a pilot study
复制标题
DOI：
10.1007/s00520-004-0746-7
复制
发表时间：
2005-04-01
影响因子：
3.1
通讯作者：
Capra, S
中科院分区：
文献类型：
--
作者：
Bauer, JD;Capra, S
本研究的目的是探讨营养干预对癌症恶病质患者接受化疗后的饮食摄入、身体成分、营养状况、功能能力和生活质量的影响，患者接受营养师每周一次的咨询，并被建议服用含有二十碳五烯酸的蛋白质和能量密集的口服营养补充剂8周。肿瘤内科医生确定了化疗方案。8名患者入组，7名完成研究。总蛋白质摄入量有显著改善（中位变化0.3g/kg/天，范围-0.1至0.8g/kg/天），总能量摄入（中位数变化36 kJ/kg/天，范围-2至82 kJ/kg/天），总纤维摄入量（中位变化6.3 g/天，范围-3.4至20.1 g/天），营养状况（患者生成的主观总体评估评分，中位变化9，范围-5至17），Karnofsky体能状态（中位数变化10，范围0-30）和生活质量（中位数变化16.7，范围0-33.3）。体重（中位变化2.3 kg;范围-2.7至4.5 kg）和瘦体重（中位变化4.4 kg，范围-4.4至4.7 kg）有临床显著改善，尽管这些改善不具有统计学显著性。营养状况的改变与生活质量的改变、Karnofsky体能状态的改变和瘦体重的改变显著相关。营养干预联合化疗可改善胰腺癌和非小细胞肺癌患者8周以上的预后。补充剂摄入不会抑制膳食摄入。
The aim of this study was to examine the effect of nutrition intervention on outcomes of dietary intake, body composition, nutritional status, functional capacity and quality of life in patients with cancer cachexia receiving chemotherapy.Patients received weekly counselling by a dietitian and were advised to consume a protein- and energy-dense oral nutritional supplement with eicosapentaenoic acid for 8 weeks. The medical oncologist determined the chemotherapy protocol. Eight patients enrolled and seven completed the study.There were significant improvements in total protein intake (median change 0.3g/kg per day, range-0.1 to 0.8g/kg per day), total energy intake (median change 36kJ/kg per day, range-2 to 82kJ/kg per day), total fibre intake (median change 6.3g/day, range-3.4 to 20.1g/day), nutritional status (patient-generated subjective global assessment score, median change 9, range-5 to 17), Karnofsky performance status (median change 10, range 0-30) and quality of life (median change 16.7, range 0-33.3). There were clinically significant improvements in weight (median change 2.3kg; range-2.7 to 4.5kg) and lean body mass (median change 4.4kg, range-4.4 to 4.7kg), although these were not statistically significant. Change in nutritional status was significantly associated with change in quality of life, change in Karnofsky performance status and change in lean body mass.Nutrition intervention together with chemotherapy improved outcomes in patients with pancreatic and non-small-cell lung cancer over 8 weeks. Supplement intake does not inhibit meal intake.