Primary and metastatic mucinous adenocarcinomas in the ovaries - Incidence in routine practice with a new approach to improve intraoperative diagnosis
Primary and metastatic mucinous adenocarcinomas in the ovaries - Incidence in routine practice with a new approach to improve intraoperative diagnosis
复制标题
DOI：
10.1097/00000478-200307000-00014
复制
发表时间：
2003-07-01
影响因子：
5.6
通讯作者：
Ronnett, BA
中科院分区：
文献类型：
--
作者：
Seidman, JD;Kurman, RJ;Ronnett, BA
据报道，粘液癌占卵巢癌的6-25%（平均12%），但最近对非侵袭性和转移性粘液癌组织学特征的解释表明，这可能是一个高估。卵巢粘液癌通常是转移性的，但原发性粘液癌与转移性粘液癌在卵巢癌患者中的比例尚不清楚。为了评估卵巢表面上皮癌的组织学类型分布，采用统一的现行标准对124例卵巢癌进行了连续系列研究。排除了微浸润性和上皮内癌以及生殖细胞和间质肿瘤中产生的癌。为了评估原发性和转移性肿瘤在粘液癌中的比例，对52例非转诊患者的粘液癌进行了回顾性分析。124例原发性卵巢癌中3例为纯粘液癌（2.4%）。卵巢粘液癌52例，转移癌40例（77%），原发癌12例（23%）。在12例原发性粘液性肿瘤中，3例为非典型增生性粘液性肿瘤伴微浸润，9例为浸润性粘液性癌。在40例转移性粘液性肿瘤中，18例（45%）来自胃肠道，8例（20%）来自胰腺，7例（18%）来自妇科恶性肿瘤（5例宫颈癌，2例子宫内膜癌），3例（8%）来自乳腺，4例（10%）原发部位不明。将所有双侧粘液癌归类为转移性单侧粘液癌的简单规则
Mucinous carcinomas are reported to comprise 6-25% of ovarian carcinomas (mean 12%), but recent refinements in the interpretation of histologic features of noninvasive and metastatic mucinous carcinomas suggest that this may be an overestimate. Mucinous carcinomas in the ovaries are commonly metastatic, but the proportion of primary versus metastatic mucinous carcinomas in unselected patients is unknown. To evaluate the histologic-type distribution of ovarian surface epithelial carcinomas, a consecutive series of 124 ovarian carcinomas was reviewed using uniform current criteria. Microinvasive and intraepithelial carcinomas and carcinomas arising in germ cell and stromal tumors were excluded. To evaluate the proportions of primary and metastatic tumors among the mucinous carcinomas, 52 consecutive mucinous carcinomas from nonreferral patients were reviewed. Three of 124 primary ovarian carcinomas were pure mucinous carcinomas (2.4%). Among 52 cases of mucinous carcinomas in the ovaries, 40 (77%) were metastatic and 12 (23%) were primary. Among the 12 primary mucinous tumors, three were atypical proliferative mucinous tumors with microinvasion and nine were invasive mucinous carcinomas. Among the 40 metastatic mucinous tumors, 18 (45%) were from the gastrointestinal tract, 8 (20%) were pancreatic, 7 (18%) were gynecologic malignancies (5 cervical, 2 endometrial), 3 (8%) were from the breast, and 4 (10%) were of unknown primary site. A simple rule that classifies all bilateral mucinous carcinomas as metastatic, unilateral mucinous carcinomas