Involvement of IL-10 Gene Promoter Polymorphisms in the Susceptibility for Childhood Asthma
Involvement of IL-10 Gene Promoter Polymorphisms in the Susceptibility for Childhood Asthma
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DOI：
10.1007/s00408-011-9312-5
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发表时间：
2011-10-01
期刊：
影响因子：
5
通讯作者：
Kim, Kyu-Earn
中科院分区：
文献类型：
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作者：
Kim, Kyung Won;Lee, Kyung Eun;Kim, Kyu-Earn
哮喘和特应性有一个复杂的背景，可能是基因和环境相互作用的结果。已知白细胞介素（IL）-10在免疫调节和抗炎反应中发挥各种作用。本研究的目的是评估IL-10启动子多态性对儿童哮喘易感性的可能影响。我们招募了333名特应性哮喘患者，55名非特应性哮喘患者和248名正常对照。我们对IL-10启动子的三种遗传多态性（IL-10 - 1082 A> G、IL-10 - 819 T> C和IL-10 - 592 A> C）进行了遗传关联研究。在这些IL-10多态性的等位基因、基因型或单倍型频率方面，特应性哮喘、非特应性哮喘和正常对照之间没有差异。IL-10启动子基因-1082A > G多态性和ATA单倍型与气道高反应性（AHR）相关，-819T > C、-592A > C、ATA和ACC单倍型与血清嗜酸性粒细胞阳离子蛋白（ECP）相关。我们的研究结果表明，IL-10启动子内的多态性可能在哮喘气道中具有疾病修饰作用。
Asthma and atopy have a complex background that may result from the interaction of genes and the environment. Interleukin (IL)-10 is known to play various roles in immune-regulating and anti-inflammatory responses. The aim of this study was to evaluate the possible effect of the IL-10 promoter polymorphisms on susceptibility to childhood asthma. We recruited 333 patients with atopic asthma, 55 with nonatopic asthma, and 248 normal controls. We performed a genetic association study of three genetic polymorphisms (IL-10 -1082A > G, IL-10 -819T > C, and IL-10 -592A > C) of the IL-10 promoter. There was no difference between atopic asthma, nonatopic asthma, and normal controls with respect to allele, genotype, or haplotype frequencies of these IL-10 polymorphisms. However, the -1082A > G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) and the -819T > C, -592A > C, and ATA and ACC haplotypes were also shown to be related to serum eosinophil cationic protein (ECP). Our results suggest that the polymorphisms within the IL-10 promoter may have a disease-modifying effect in the asthmatic airway.