Kanamycin induced low-frequency hearing loss in the budgerigar (Melopsittacus undulatus).
Kanamycin induced low-frequency hearing loss in the budgerigar (Melopsittacus undulatus).
复制标题
卡那霉素会导致虎皮鹦鹉（Melopsittacus undulatus）低频听力损失。
DOI：
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复制
发表时间：
1989
影响因子：
2.4
通讯作者：
M. Sokabe
中科院分区：
文献类型：
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作者：
E. Hashino;M. Sokabe
采用行为测听法研究了卡那霉素（KM）对虎皮鹦鹉听力的慢性影响。连续10天每天肌肉注射KM（100 mg/kg或200 mg/kg），并比较治疗前后的绝对阈值。KM引起短暂性和永久性低频特异性听力损失;即，1 kHz以下频率的阈值升高大于1 kHz以上频率。此外，听力损失的程度与剂量有关。本研究中KM的低频选择性作用与哺乳动物中氨基糖苷类耳毒性的高频特异性相反。为了评估KM对听觉频率分辨率的影响，在具有低频特异性听力损失的病理性鸟类中估计了临界比率。临界比的变化与绝对阈值的变化呈线性关系，表明临界比的增加是由于探测器机制效率的降低而不是鸟类光谱分辨能力的改变。
The chronic effects of kanamycin (KM) on hearing in the budgerigar were investigated by behavioral audiometry. The birds received a daily intramuscular injection of KM (100 mg/kg or 200 mg/kg) for 10 successive days, and absolute thresholds between pre- and post-treatment were compared. KM induced both transient and permanent low-frequency specific hearing loss; i.e., the elevation of threshold for frequencies below 1 kHz was greater than that for frequencies above 1 kHz. Moreover, the degree of hearing loss was dose dependent. The low-frequency selective effects of KM in the present study were contrary to the high-frequency specificity of aminoglycoside ototoxicity in mammals. To assess the effect of KM on auditory frequency resolution, critical ratios were estimated in pathological birds with low-frequency specific hearing loss. There was a linear relation between shift in critical ratio and shift in absolute threshold, suggesting that the increase in the critical ratio is due to a decrease in the efficiency of the detector mechanism rather than a change in the spectral resolving power of the birds.