Developing a new resource for drug discovery: marine actinomycete bacteria
Developing a new resource for drug discovery: marine actinomycete bacteria
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DOI：
10.1038/nchembio841
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发表时间：
2006-12-01
影响因子：
14.8
通讯作者：
Jensen, Paul R.
中科院分区：
文献类型：
--
作者：
Fenical, William;Jensen, Paul R.
天然产品既是新的化学多样性的基本来源，也是当今药物纲要的组成部分。然而，人们对天然药物发现的兴趣已经减弱，部分原因是土壤细菌等传统资源的回报越来越少。海洋覆盖了地球表面的70%，并拥有地球上大部分的生物多样性。虽然海洋植物和无脊椎动物作为天然产品发现的资源受到了相当大的关注，但这种多样性的微生物成分仍然相对未被探索。最近的研究表明，选定的海洋放线菌群是新的天然产物的强大来源。Salinispora属的成员已被证明是新化学结构的特别丰富的来源，包括有效的蛋白酶体抑制剂salinosporamide A，其他不同的群体正在产生新类别的萜类化合物，氨基酸衍生的代谢物和多烯大环内酯。继续开发更好的养殖方法和技术，以利用深海环境，有望提供利用这一重要的化学多样性新来源的机会。
Natural products are both a fundamental source of new chemical diversity and an integral component of today's pharmaceutical compendium. Yet interest in natural-product drug discovery has waned, in part owing to diminishing returns from traditional resources such as soil bacteria. The oceans cover 70% of the Earth's surface and harbor most of the planet's biodiversity. Although marine plants and invertebrates have received considerable attention as a resource for natural-product discovery, the microbiological component of this diversity remains relatively unexplored. Recent studies have revealed that select groups of marine actinomycetes are a robust source of new natural products. Members of the genus Salinispora have proven to be a particularly rich source of new chemical structures, including the potent proteasome inhibitor salinosporamide A, and other distinct groups are yielding new classes of terpenoids, amino acid-derived metabolites and polyene macrolides. The continued development of improved cultivation methods and technologies for accessing deep-sea environments promises to provide access to this significant new source of chemical diversity.