Cerebral cortical registration of subliminal visceral stimulation
Cerebral cortical registration of subliminal visceral stimulation
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DOI：
10.1053/gast.2002.30989
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发表时间：
2002-02-01
期刊：
影响因子：
29.4
通讯作者：
Shaker, R
中科院分区：
文献类型：
--
作者：
Kern, MK;Shaker, R
背景与目的：虽然先前已经报道了阈下躯体刺激（例如掩蔽视觉刺激）的大脑记录及其对大脑活动的电和血流动力学测量的影响，但尚未有关于阈下内脏刺激的大脑皮层记录的报道。因为评估阈下躯体刺激后果的研究表明，阈下刺激可以影响行为，所以可以想象，来自肠道的这种阈下信息可能会影响肠道感觉/运动功能，或影响对源自肠道的感觉信号的感知/解释。方法：我们研究了健康志愿者的大脑皮层功能磁共振成像 (fMRI) 对阈下、阈下和阈上直肠扩张的反应。结果：研究结果表明，源自肠道的阈下传入信号在大脑皮层中被记录，但没有达到意识水平。肠道阈下刺激引起的皮质活动部位与阈下刺激和阈上刺激相似，但强度和体积显着较低（P < 0.05）。结论：源自肠道的阈下传入信号在大脑皮层中被记录，并引起大脑活动测量的变化，例如通过功能磁共振成像检测到的血流动力学变化。
Background & Aims: Although brain registration of subliminal somatic stimulations such as masked visual stimuli and their influence on electrical and hemodynamic measures of cerebral activity have been reported previously, there have been no reports on cerebral cortical registration of subliminal visceral stimulation. Because studies evaluating the consequences of subliminal somatic stimulation have shown that subliminal stimulation can effect behavior, it is conceivable that such subliminal messages from the intestine could potentially influence intestinal sensory/motor function or effect the perception/interpretation of sensory signals originating from the gut. Methods: We studied the cerebral cortical functional magnetic resonance imaging (fMRI) response to subliminal, liminal, and supraliminal rectal distention in healthy volunteers. Results: Study findings Indicate that subliminal afferent signals originating from the gut are registered in the cerebral cortex without reaching the level of awareness. Locations of cortical activity caused by intestinal subliminal stimulation are similar to those of liminal and supraliminal stimulation but their intensity and volume are significantly lower (P < 0.05). Conclusions: Subliminal afferent signals originating from the gut are registered in the cerebral cortex and induce changes in measures of brain activity, such as hemodynamic changes detectable by fMRI.