Prognostic significance of tumor budding thresholds in oral tongue squamous cell carcinoma
Prognostic significance of tumor budding thresholds in oral tongue squamous cell carcinoma
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DOI：
10.1111/odi.14193
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发表时间：
2022-04-16
期刊：
影响因子：
3.8
通讯作者：
Troiano, Giuseppe
中科院分区：
文献类型：
--
作者：
Mascitti, Marco;Togni, Lucrezia;Troiano, Giuseppe
口腔舌鳞状细胞癌是口腔最常见的恶性肿瘤。肿瘤出芽（TB）是OTSCC的可靠预后因素;然而，标准化评分系统尚未得到验证。该研究旨在评估结核病在1997年至2018年间治疗的211例OTSCC患者中的预后作用。材料与方法在浸润前沿热点区域的苏木精和伊红染色切片上评估TB（放大200倍）。采用两级评分法、三级评分法、BD评分法和改良评分法进行评分。采用单因素和多因素考克斯回归分析方法对患者的疾病特异性生存期（DSS）和无病生存期（DFS）进行分析。这些数据证实了TB在预测OTSCC中的DSS中的预后价值。使用5-芽截止值将患者分为两组可显著区分其结果。结论由于DOI的作用已被确立，且分级的预后价值较差，TB可作为独立的预后指标。
Background Oral tongue squamous cell carcinoma (OTSCC) represents the most common malignancy of the oral cavity. Tumor budding (TB) is a reliable prognostic factor in OTSCC; however, a standardized scoring system is not still validated. Aims The study aims to evaluate the prognostic role of TB in 211 OTSCC patients treated between 1997 and 2018. Materials & Methods TB was evaluated on hematoxylin and eosin-stained sections in the hotspot area of the infiltrative front (x200-magnification). It was scored using a two-tier system, a three-tier system, and according to BD-model and revised-Grading system. Univariate and multivariate Cox regression analyses of disease-specific survival (DSS) and disease-free survival (DFS) were performed. A p These data confirm the prognostic value of TB in predicting DSS in OTSCC. Classifying patients into two groups using the 5-bud cutoff significantly discriminates their outcomes. Conclusion Since the established role of DOI and the poor prognostic value of grading, TB could be considered an independent prognostic marker.