mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity
mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity
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DOI：
10.1038/sj.mp.4002073
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发表时间：
2008-10-01
影响因子：
11
通讯作者：
Flor, P. J.
中科院分区：
文献类型：
--
作者：
Fendt, M.;Schmid, S.;Flor, P. J.
哺乳动物大脑中厌恶性记忆的形成和消失在细胞和分子水平上还没有得到充分的理解。使用新的代谢型谷氨酸受体7（mGluR7）激动剂AMN082，我们证明，mGluR7激活促进在两个不同的杏仁核依赖性任务的厌恶记忆的灭绝。相反，mGluR7敲低使用短干扰RNA减弱了学习厌恶的消退。mGluR7激活还阻断了巴甫洛夫恐惧学习的获得及其在杏仁核中的电生理相关的长时程增强。mGluR7除了获得令人厌恶的记忆外，还对灭绝有着重要的调节作用，这一发现表明。
Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates.