Evidence that nerve growth factor mediates the formation of sensory pericellular baskets in the rat trigeminal ganglion.
Evidence that nerve growth factor mediates the formation of sensory pericellular baskets in the rat trigeminal ganglion.
复制标题
有证据表明神经生长因子介导大鼠三叉神经节感觉细胞周篮的形成。
DOI：
10.1016/s0304-3940(02)00874-1
复制
发表时间：
2002
影响因子：
2.5
通讯作者：
Isaacson,LG
中科院分区：
文献类型：
--
作者：
Shoemaker,SE;Isaacson,LG
研究了神经生长因子（NGF）在三叉神经节感觉神经元重塑中的作用。脑室内神经生长因子输注和/或双侧交感上级颈神经节，这两者都被认为是增加神经生长因子的初级感觉神经元的可用性，导致降钙素基因相关肽免疫反应性细胞周围篮的频率显着增加。这项研究的结果表明，增加的神经生长因子是足够的，以提高在这个神经节中的感觉篮的形成，并提供证据表明，神经生长因子可能介导的感觉神经节损伤后的感觉篮的形成。
A role for nerve growth factor (NGF) in the remodeling of sensory neurons in the trigeminal ganglion was examined. Intracerebroventricular NGF infusion and/or bilateral removal of the sympathetic superior cervical ganglia, both of which are believed to increase the availability of NGF to primary sensory neurons, resulted in a significant increase in the frequency of calcitonin gene-related peptide immunoreactive pericellular baskets. The results of this study suggest that increased NGF is sufficient to enhance the formation of sensory baskets in this ganglion, and provide evidence that NGF may mediate the formation of sensory baskets in the sensory ganglia following injury.