Collagen cross-linking and ultimate tensile strength in dentin
Collagen cross-linking and ultimate tensile strength in dentin
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DOI：
10.1177/154405910408301014
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发表时间：
2004-10-01
影响因子：
7.6
通讯作者：
Yamauchi, M
中科院分区：
文献类型：
--
作者：
Miguez, PA;Pereira, PNR;Yamauchi, M
多项研究表明牙科材料与牙冠和牙根牙本质的粘合强度存在差异。为了研究这些位置之间基质特性的潜在差异，我们分析了人类第三磨牙的上根和牙冠牙本质的极限拉伸强度和胶原蛋白生物化学。在这两个位置，垂直于牙本质小管方向（未脱矿冠= 140.4 +/- 48.6/根= 95.9 +/- 26.1；脱矿冠= 16.6 +/- 6.3/根= 29.0 +/- 12.4）测试的拉伸强度大于平行于牙本质小管方向测试的拉伸强度（未脱矿冠= 73.1 +/- 21.2/根= 63.2 +/- 22.6；脱矿牙冠= 9.0 +/- 3.9/根= 16.2 +/- 8.0）。脱矿质标本的根部抗拉强度明显高于冠部。尽管两个位置的胶原蛋白含量相当，但与牙冠相比，根部的两种主要胶原蛋白交联，脱氢二羟基赖氨酸正亮氨酸/其酮胺和吡啶啉显着较高（分别接近 30% 和接近 55%）。这些结果表明，胶原蛋白交联的分布随牙本质解剖位置的变化而变化，并且这种差异可以部分解释位点特异性拉伸强度。
Several studies have indicated differences in bond strength of dental materials to crown and root dentin. To investigate the potential differences in matrix properties between these locations, we analyzed upper root and crown dentin in human third molars for ultimate tensile strength and collagen biochemistry. In both locations, tensile strength tested perpendicular to the direction of dentinal tubules ( undemineralized crown = 140.4 +/- 48.6/root = 95.9 +/- 26.1; demineralized crown = 16.6 +/- 6.3/root = 29.0 +/- 12.4) was greater than that tested parallel to the tubular direction ( undemineralized crown = 73.1 +/- 21.2/root = 63.2 +/- 22.6; demineralized crown = 9.0 +/- 3.9/ root = 16.2 +/- 8.0). The demineralized specimens showed significantly greater tensile strength in root than in crown. Although the collagen content was comparable in both locations, two major collagen cross-links, dehydrodihydroxylysinonorleucine/ its ketoamine and pyridinoline, were significantly higher in the root ( by similar to 30 and similar to 55%, respectively) when compared with those in the crown. These results indicate that the profile of collagen cross-linking varies as a function of anatomical location in dentin and that the difference may partly explain the site-specific tensile strength.