Cognition in rapid eye movement sleep behavior disorder.
Cognition in rapid eye movement sleep behavior disorder.
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DOI：
10.3389/fneur.2012.00082
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发表时间：
2012
影响因子：
3.4
通讯作者：
Génier Marchand D
中科院分区：
文献类型：
--
作者：
Gagnon JF;Bertrand JA;Génier Marchand D
快速眼动（REM）睡眠行为障碍（RBD）是一种以REM睡眠期间过度的肌肉活动和不期望的运动事件为特征的异眠症。RBD发生在大约0.5%的普通人群中，老年男性的患病率更高。RBD是路易体痴呆（DLB）的常见特征，但在阿尔茨海默病中很少报道。RBD也是α-突触核蛋白相关疾病的风险因素，如DLB，帕金森病（PD）和多系统萎缩。因此，RBD对于神经退行性疾病的诊断和治疗以及理解特定的神经退行性疾病模式具有重要意义。在RBD中已经确定了几种神经变性的标志物，包括认知障碍，如注意力、执行功能、学习能力和视觉空间能力的缺陷。大约50%的RBD患者存在轻度认知障碍。此外，RBD还与PD的认知下降有关。
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by excessive muscle activity and undesirable motor events during REM sleep. RBD occurs in approximately 0.5% of the general population, with a higher prevalence in older men. RBD is a frequent feature of dementia with Lewy bodies (DLB), but is only rarely reported in Alzheimer’s disease. RBD is also a risk factor for α-synuclein-related diseases, such as DLB, Parkinson’s disease (PD), and multiple system atrophy. Therefore, RBD has major implications for the diagnosis and treatment of neurodegenerative disorders and for understanding specific neurodegeneration patterns. Several markers of neurodegeneration have been identified in RBD, including cognitive impairments such as deficits in attention, executive functions, learning capacities, and visuospatial abilities. Approximately 50% of RBD patients present mild cognitive impairment. Moreover, RBD is also associated with cognitive decline in PD.