Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.
Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.
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DOI：
10.1093/oxfordjournals.molbev.a040410
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发表时间：
1986-01
影响因子：
10.7
通讯作者：
M. Nei;T. Gojobori
中科院分区：
文献类型：
--
作者：
M. Nei;T. Gojobori
提出了两种估计同义和非同义核苷酸取代数量的简单方法。尽管它们没有对不同类型的密码子取代赋予权重，但这些方法给出的结果基本上与 Miyata 和 Yasunaga 以及 Li 等人的方法获得的结果相同。计算机模拟表明，除非每个位点的核苷酸取代数量非常大，否则通过这两种方法获得的同义取代的估计是相当准确的。结果表明，当非同义替换的数量很大时，所有可用的方法都倾向于低估非同义替换的数量。
Two simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions are presented. Although they give no weights to different types of codon substitutions, these methods give essentially the same results as those obtained by Miyata and Yasunaga's and by Li et al.'s methods. Computer simulation indicates that estimates of synonymous substitutions obtained by the two methods are quite accurate unless the number of nucleotide substitutions per site is very large. It is shown that all available methods tend to give an underestimate of the number of nonsynonymous substitutions when the number is large.