‘O-GlcNAc Code’ Mediated Biological Functions of Downstream Proteins
‘O-GlcNAc Code’ Mediated Biological Functions of Downstream Proteins
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DOI：
10.3390/molecules23081967
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Jingji Jin
中科院分区：
文献类型：
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作者：
Linhong Zhao;Junaid Ali Shah;Yong Cai;Jingji Jin
As one of the post-translational modifications, O-linked β-N-acetylglucosamine (O-GlcNAc).modification (O-GlcNAcylation) often occurs on serine (Ser) and threonine (Thr) residues of specific.substrate cellular proteins via the addition of O-GlcNAc group by O-GlcNAc transferase (OGT)..Maintenance of normal intracellular levels of O-GlcNAcylation is controlled by OGT and glycoside.hydrolase O-GlcNAcase (OGA). Unbalanced O-GlcNAcylation levels have been involved in many.diseases, including diabetes, cancer, and neurodegenerative disease. Recent research data reveal.that O-GlcNAcylation at histones or non-histone proteins may provide recognition platforms for.subsequent protein recruitment and further initiate intracellular biological processes. Here, we review.the current understanding of the ‘O-GlcNAc code’ mediated intracellular biological functions of.downstream proteins.
