Clinically detectable structural abnormalities in pediatric-onset multiple sclerosis: A large-scale magnetic resonance imaging analysis.
Clinically detectable structural abnormalities in pediatric-onset multiple sclerosis: A large-scale magnetic resonance imaging analysis.
复制标题
儿科发病的多发性硬化症临床可检测的结构异常：大规模磁共振成像分析。
DOI：
10.1002/jdn.10090
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Takahashi,Emi
中科院分区：
文献类型：
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作者：
Levman,Jacob;Das,Avilash;MacDonald,Allissa;MacDonald,Patrick;Berrigan,Lindsay;Takahashi,Emi
背景多发性硬化症的特征是神经脱髓鞘。结构性磁共振成像 (MRI) 提供软组织对比，这构成了提取参与者大脑区域生物标志物的技术的基础。目标在大规模 MRI 分析中研究多发性硬化症的临床表现，其中包括全面考虑可提取的结构测量（区域皮质厚度、皮质表面测量和体积的平均值和变异性）。方法我们对 64 名参与者的 370 个 T1 结构体积 MRI 进行了大规模回顾性分析，多发性硬化症，并将其与一大群神经典型参与者进行比较，其中包括来自 988 名参与者的 993 幅 MRI。提取皮质厚度的区域分布测量值（平均值和标准差）以及表面积、表面曲率和体积测量值。结果观察到的最大发现涉及平均皮质厚度的区域分布减少，其中海马旁区域表现出最大的效应大小，这一发现可能与多发性硬化症中已知的海马萎缩有关。在分布体积、表面积和表面曲率测量方面也观察到了组间差异。 结论 患有儿科发病的多发性硬化症的参与者在临床上表现出多种结构异常，包括以前文献中未报道的鼻周皮层厚度异常。
BackgroundMultiple Sclerosis is characterized by neural demyelination. Structural magnetic resonance imaging (MRI) provides soft tissue contrast, which forms the basis of techniques for extracting regional biomarkers across a participant's brain.ObjectivesTo investigate the clinical presentation of multiple sclerosis in a large‐scale MRI analysis that includes thorough consideration of extractable structural measurements (average and variability of regional cortical thicknesses, cortical surface measurements, and volumes).MethodsWe performed a large‐scale retrospective analysis of 370 T1 structural volumetric MRIs from 64 participants with multiple sclerosis and compared them with a large cohort of neurotypical participants, consisting of 993 MRIs from 988 participants. Regionally distributed measurements of cortical thickness (average and standard deviation) were extracted along with surface area, surface curvature, and volumetric measurements.ResultsThe largest observed finding involved regionally distributed reductions in average cortical thickness, with the parahippocampal region exhibiting the largest effect size, a finding that may be linked with known hippocampal atrophy in multiple sclerosis. Group‐wise differences were also observed in terms of distributed volume, surface area, and surface curvature measurements.ConclusionsParticipants with pediatric‐onset multiple sclerosis present clinically with a variety of structural abnormalities, including perirhinal cortex thickness abnormalities not previously reported in the literature.