Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease.
Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease.
复制标题
CRL4泛素连接酶在人类疾病中的致病作用。
DOI：
10.3389/fonc.2012.00021
复制
发表时间：
2012
影响因子：
4.7
通讯作者：
Zhou P
中科院分区：
文献类型：
--
作者：
Lee J;Zhou P
The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1–CUL4 associated factors substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions. Aberrant expression of the cullin 4A (CUL4A) gene is found in many tumor types, while mutations of the cullin 4B (CUL4B) gene are causally associated with human X-linked mental retardation. This focused review will summarize our current knowledge of the two CUL4 family members in the pathogenesis of human malignancy and neuronal disease, and discuss their potential as new targets for cancer prevention and therapeutic intervention.
