[Experimental study of the effect of combined treatment of UFT with CDDP on human solid tumor-xenografts in nude mice].
[Experimental study of the effect of combined treatment of UFT with CDDP on human solid tumor-xenografts in nude mice].
复制标题
UFT与CDDP联合治疗人实体瘤裸鼠移植瘤效果的实验研究
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
S. Takeda
中科院分区：
文献类型：
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作者：
Y. Yamada;H. Saito;S. Oie;T. Takechi;K. Nakano;S. Takeda
研究了UFT和CDDP联合给药的效果，特别是最佳的时间依赖性给药顺序，在临床同等剂量和给药途径下，在荷人胃癌、结肠癌、肺癌、乳腺癌和宫颈癌的裸鼠身上进行了治疗。在9种癌症中，有7种联合治疗的有效率高于单一治疗(78%)。然而，UFT和CDDP的联合时机被认为是产生良好疗效的重要因素，因为联合治疗的效果因治疗程序的不同而不同，例如UFT先用CDDP或先用CDDP再用UFT。联合作用与治疗程序、组织来源、组织学、癌细胞倍增时间及单药疗效的相关性较低。UFT在CDDP前和CDDP后均有最强的抗肿瘤作用。这种治疗程序似乎对来历不明或性质不明的癌症是合理的。
The effect of combined treatment of UFT with CDDP, especially the optimal time-dependent administration sequence, was studied in nude mice bearing nine human cancer xenografts derived from stomach, colon, lung, breast and uterocervical cancers following treatment with clinically equivalent doses and routes of administration. This combination treatment produced a higher response rate than a single treatment in 7 out of 9 cancers (78%). However, the combination timing of UFT and CDDP was assumed to be an important factor to produce a good therapeutic effect, since the combination effect was different by changing the treatment procedure, e.g., UFT followed by CDDP or CDDP followed by UFT. There was a low correlation between combination effect and the treatment procedure, origin of tissues, histology and doubling time of cancer cells or efficacy of a single agent. The strongest antitumor effect was observed by the treatment with UFT administered both prior to CDDP and after CDDP. Such treatment procedure seemed to be reasonable for cancers of unknown origin or character.