Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia.
Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia.
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DOI：
10.3389/fmed.2015.00023
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发表时间：
2015
影响因子：
3.9
通讯作者：
Fatica A
中科院分区：
文献类型：
--
作者：
Morlando M;Ballarino M;Fatica A
长链非编码RNA（lncRNA）是基因表达的重要调节因子，其影响基因生命周期的几乎每一个步骤，从转录到mRNA剪接、RNA降解和翻译。除了参与正常的生理功能外，lncRNA的表达和功能已经与癌症的发生和发展有关。在这里，我们回顾lncRNA在正常造血中的功能作用和作用机制，以及它们的失调如何可能与血细胞癌（如白血病）的发展有关。
Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation. Besides their participation to normal physiology, lncRNA expression and function have been already associated to cancer development and progression. Here, we review the functional role and mechanisms of action of lncRNAs in normal hematopoiesis and how their misregulation may be implicated in the development of blood cell cancer, such as leukemia.