Contrasting effects of reward expectation on sensory and motor memories in primate prefrontal neurons
Contrasting effects of reward expectation on sensory and motor memories in primate prefrontal neurons
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DOI：
10.1093/cercor/bhj042
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发表时间：
2006-07-01
期刊：
影响因子：
3.7
通讯作者：
Sawaguchi, Toshiyuki
中科院分区：
文献类型：
--
作者：
Amemori, Ken-ichi;Sawaguchi, Toshiyuki
通过成功的行为获得的奖励的价值对于指导有目的的行为是重要的。外侧前额叶皮质(LPFC)与指导目标导向行为的工作记忆有关。然而，将奖赏价值整合到目标导向行为的工作记忆中的机制还不清楚。为了帮助阐明这个问题，我们研究了奖赏期望对LPFC中神经元过程的影响，该过程与基于记忆的感觉运动加工有关。通过在LPFC中时间分离视觉空间感觉记忆和扫视定向运动记忆，我们发现奖赏期望显著提高了感觉工作记忆的方向选择性，但不影响运动记忆的方向选择性。神经元群体中感觉工作记忆的增强在延迟期间持续，但在运动记忆出现后不久就消失了。这些结果表明，对高奖励值的期望主要影响可能用于行为指导的感觉工作记忆，而不是为即将到来的眼跳做准备。因此，LPFC似乎是用于指导奖赏导向行为的工作记忆的神经元底物，而不是反映在激励状态下对运动动作的有效控制。
The value of reward obtained with successful behavior is important for guiding purposeful behavior. The lateral prefrontal cortex (LPFC) has been implicated in working memory that guides goal-directed behavior. However, mechanism that integrates the reward value into the working memory for goal-directed behavior is not understood. To help clarify this issue, we examined the effect of reward expectation on the neuronal process in the LPFC associated with memory-based sensorimotor processing. By temporally dissociating visuospatial sensory and saccade-directional motor memories in the LPFC, we here show that reward expectation significantly enhanced the directional selectivity of sensory working memory but did not affect the directional selectivity of motor memory. The enhancement of sensory working memory in the neuronal population was sustained during the delay but extinguished soon after the motor memory appeared. These results suggest that the expectation of high reward value primarily affects the sensory working memory that may be used for behavioral guidance rather than preparation for forthcoming saccades. It thus appears that the LPFC is a neuronal substrate for working memory used to guide a reward-oriented behavior, rather than reflecting an efficient control of motor action in motivated states.