18F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis
18F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis
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DOI：
10.1016/j.atherosclerosis.2017.04.024
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发表时间：
2017-08-01
期刊：
影响因子：
5.3
通讯作者：
Kihara, Yasuki
中科院分区：
文献类型：
--
作者：
Kitagawa, Toshiro;Yamamoto, Hideya;Kihara, Yasuki
背景与目的：我们旨在评价正电子发射断层扫描(PET)摄取F-18-NaF与CT检测冠状动脉粥样硬化的关系。方法：32例心脏CT发现一个或多个冠状动脉粥样硬化病变的患者接受了F-18-NaF PET/CT检查。每个冠状动脉粥样硬化病变均在CT血管成像上评估斑块类型(钙化斑块[CP]、非钙化斑块[NCP]、部分钙化斑块[PCP])，以及是否存在基于CT的高危特征(最低CT密度1.1)。使用最大组织与背景比(TBRmax)来定量每个病灶的局灶性F-18-NaF摄取。在一项基于患者的分析中，经对数变换的冠状动脉钙化分数与每名患者的最大TBRmax呈正相关，15名有心肌梗死或不稳定心绞痛病史的患者的每名患者的最大TBRmax高于无此病史的患者(1.36+/-0.15vs1.15+/-0.15，p=0.0006)。在基于病变的分析中，PCP的TBRmax高于CP和NCP(分别为1.17+/-0.19和1.00+/-0.24和0.92+/-0.18，p<；结论：冠状动脉F-18-NaF摄取与总斑块负荷、冠脉事件史及冠状动脉粥样硬化的具体特征有关。F-18-NaF PET/CT结合心脏CT可能为识别高危患者和冠状动脉粥样硬化病变提供一种新的分子成像方法。(C)2017爱思唯尔B.V.保留所有权利。
Background and aims: We aimed at evaluating the relation of F-18-sodium fluoride (F-18-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT).Methods: Thirty-two patients with one or more coronary atherosclerotic lesions detected on cardiac CT underwent F-18-NaF PET/CT. Each coronary atherosclerotic lesion was evaluated on CT angiography for plaque types (calcified plaque [CP], non-calcified plaque [NCP], partially calcified plaque [PCP]), and the presence of CT-based high-risk features (minimum CT density 1.1). Focal F-18-NaF uptake of each lesion was quantified using maximum tissue-to-background ratio (TBRmax).Results: A total of 111 lesions were studied. In a patient-based analysis, logarithmically transformed coronary calcium score correlated positively with maximum TBRmax per patient, and 15 patients with myocardial infarction or unstable angina history showed a higher maximum TBRmax per patient than those without (1.36 +/- 0.15 versus 1.15 +/- 0.15, p = 0.0006). In a lesion-based analysis, PCP showed a higher TBRmax than CP and NCP (1.17 +/- 0.19 versus 1.00 +/- 0.24 and 0.92 +/- 0.18, respectively, p < 0.0001), and the lesions with high-risk features had a higher TBRmax than those without (1.20 +/- 0.21 versus 1.02 +/- 0.20, p = 0.0011).Conclusions: Coronary arterial F-18-NaF uptake is related to total plaque burden, coronary event history, and specific features of coronary atherosclerosis based on CT analysis. F-18-NaF PET/CT, in combination with cardiac CT, may provide a new molecular imaging approach to identify high-risk patients and coronary atherosclerotic lesions. (C) 2017 Elsevier B.V. All rights reserved.