Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery.
Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery.
复制标题
DOI：
10.4317/jced.51868
复制
发表时间：
2015-04-01
影响因子：
--
通讯作者：
Babaji, Harsha V
中科院分区：
文献类型：
--
作者：
Chappi D, Mouneshkumar;Suresh, Kandagal V;Babaji, Harsha V
背景：下颌第三磨牙的手术拔除会导致一定程度的术后疼痛、肿胀和牙关紧闭。这些可以通过适当的局部麻醉、小心的骨切除、对邻近软组织的最小创伤以及甲基强的松龙和沙雷肽酶药物的给药来控制。本研究的目的是比较甲基强的松龙和serratiopeptidase在控制术后疼痛，肿胀和牙关紧闭后，手术切除阻生下颌第三磨牙的疗效。材料和方法：受试者被分为两组，每组50例患者进行手术切除下颌第三磨牙。A组给予甲泼尼龙4 mg，每8小时口服一次; B组给予血清肽酶10 mg，每12小时口服一次。结果：甲基强的松龙是一种有效的镇痛药物，而舍曲肽酶具有中等程度的镇痛作用。在控制术后肿胀和牙关紧闭方面，Serratiopeptidase比甲基强的松龙更有效。因此，这两种药物的组合将是非常有效的，比单独的药物时，广泛的术后后遗症，预计手术切除后的影响下第三磨牙。结论：我们得出结论，甲泼尼龙提供更好的疼痛缓解，而serratiopeptidase发挥更好的抗炎和抗肿胀作用，在术后期间。然而，当预期有广泛的术后后遗症时，这两种药物的协同组合将被证明更有效。关键词：甲泼尼龙，沙雷肽酶，疼痛，肿胀，牙关紧闭，第三磨牙。
BACKGROUND: Surgical removal of mandibular third molars results in some degree of post-operative pain, swelling and trismus. These can be controlled by proper administration of local anesthesia, careful bone removal, minimal trauma to adjacent soft tissues and administration of methylprednisolone and serratiopeptidase drugs. The aim of the present study was to compare the efficacy of methylprednisolone and serratiopeptidase in controlling post-operative pain, swelling and trismus after surgical removal of impacted mandibular third molars.MATERIAL AND METHODS: The subjects were divided into two groups of 50 patients each undergoing surgical removal of mandibular third molars. Group A was given methylprednisolone 4mg orally every 8th hourly and Group B was given serratiopeptidase 10 mg every 12th hourly orally. Post-operatively pain, swelling and trismus were evaluated at the end of 1st, 3rd and 5thday.RESULTS: The results of this study showed that methylprednisolone is an effective analgesic, while serratiopeptidase has moderate analgesic activity. Serratiopeptidase is more effective than methylprednisolone in controlling post surgical swelling and trismus. Hence combination of these two drugs would be very effective than individual drug when widespread post-operative sequelae are expected after surgical removal of impacted lower third molars.CONCLUSIONS: We conclude that methylprednisolone affords better pain relief while serratiopeptidase exerts better anti-inflammatory and anti-swelling effects in the post-operative period. Synergistic combinations of these two drugs would however prove to be more effective when extensive post-operative sequelae are expected. Key words:Methylprednisolone, serratiopeptidase, pain, swelling, trismus, third molar.