The role of IL-18 in Th1/Th2 balance in children
The role of IL-18 in Th1/Th2 balance in children
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DOI：
10.2500/aap.2006.27.2894
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发表时间：
2006-07-01
影响因子：
2.8
通讯作者：
Agachan, Nevin
中科院分区：
文献类型：
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作者：
Cebeci, A. Nurcan;Nuhoglu, Yonca;Agachan, Nevin
白细胞介素(IL)-18已被确定为诱导1型辅助（Th1）细胞、CD8(+) T细胞和自然杀伤细胞释放干扰素γ的介质，与IL-12协同作用。一些研究报道了IL-18的不同作用；但对IL-18在儿童Th1/Th2平衡中的作用知之甚少。本研究的目的是评估IL-18在Th1和th2介导的儿童疾病中的作用。在急性哮喘加重患者组（n = 24）、最近被诊断为I型胰岛素依赖型糖尿病患者组（n = 18）和健康受试者组（n = 20）中测量血清IL-18水平。比较各组IL-18水平。急性哮喘患者（中位数为8.55 pg/mL）和胰岛素依赖型糖尿病患者（中位数为7.20 pg/mL）血清IL-18水平显著低于对照组（中位数为140.10 pg/mL, p < 0.05和p < 0.001）。我们认为IL-18可能在过敏性和自身免疫性疾病中发挥免疫调节作用，IL-18表达降低可以将免疫反应转变为Th1和th2介导的方式。
Interleukin (IL)-18 has been identified as a mediator inducing interferon gamma release from type 1 helper (Th1) cells, CD8(+) T cells, and natural killer cells, synergizing with IL-12. Several studies report differential roles of IL-18; but little is known about the role of IL-18 in Th1/Th2 balance in children. The aim of this study was to evaluate the role of IL-18 in Th1- and Th2-mediated diseases of children. Serum IL-18 levels were measured in a group of patients with acute asthma exacerbation (n = 24), in a group of patients who had recently been diagnosed as type I insulin-dependent diabetes mellitus (n = 18), and in a group of healthy subjects (n = 20). The groups were compared with respect to IL-18 levels. Significantly lower serum IL-18 levels were found in patients with acute asthma (median, 8.55 pg/mL) and insulin-dependent diabetes mellitus (median, 7.20 pg/mL) than in control subjects (median, 140.10 pg/mL; p < 0.05 and p < 0.001, respectively). We suggest that IL-18 may play an immunoregulatory role in allergic and autoimmune diseases and decreased expression of IL-18 can shift the immune responses to both Th1- and Th2-mediated ways.