Control of dendritic field formation in Drosophila:: The roles of flamingo and competition between homologous neurons
Control of dendritic field formation in Drosophila:: The roles of flamingo and competition between homologous neurons
复制标题
DOI：
10.1016/s0896-6273(00)00088-x
复制
发表时间：
2000-10-01
期刊：
影响因子：
16.2
通讯作者：
Jan, YN
中科院分区：
文献类型：
--
作者：
Gao, FB;Kohwi, M;Jan, YN
神经元用刻板的分支模式精心制作树突，从而定义它们的感受野。这些分支模式可能源于神经元固有的特性或相邻神经元之间的竞争。遗传学和激光消融研究表明，在果蝇胚胎PNS的同一背侧簇不同的多个树突状神经元不相互竞争的树突领域。与此相反，当树突同源神经元在两个hemisegments满足在背中线幼虫阶段，他们似乎互相排斥。正常树突野的形成和同源神经元树突之间的竞争需要Flamingo（一种G蛋白偶联受体样蛋白）在胚胎神经元中的适当表达水平。而火烈鸟的功能下游卷曲在指定平面极性，火烈鸟依赖的树突生长是独立的卷曲。
Neurons elaborate dendrites with stereotypic branching patterns, thereby defining their receptive fields. These branching patterns may arise from properties intrinsic to the neurons or competition between neighboring neurons. Genetic and laser ablation studies reported here reveal that different multiple dendritic neurons in the same dorsal cluster in the Drosophila embryonic PNS do not compete with one another for dendritic fields. In contrast, when dendrites from homologous neurons in the two hemisegments meet at the dorsal midline in larval stages, they appear to repel each other. The formation of normal dendritic fields and the competition between dendrites of homologous neurons require the proper expression level of Flamingo, a G protein-coupled receptor-like protein, in embryonic neurons. Whereas Flamingo functions downstream of Frizzled in specifying planar polarity, Flamingo-dependent dendritic outgrowth is independent of Frizzled.