Beneficial effect of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats.
Beneficial effect of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats.
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新型利尿剂 M17055 对自发性高血压大鼠的血压和心血管肥大的有益作用。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
M. Mizota
中科院分区：
文献类型：
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作者：
T. Shinkawa;Y. Kato;N. Tsuchiya;F. Yamasaki;A. Uemura;M. Mizota
我们研究了一种新型利尿剂M17055对自发性高血压大鼠（SHR）血压和心血管肥大的影响。14周龄男性SHR口服M17055，每天1次，连续24天。在治疗期间，剂量为1.25、2.5和5 mg/kg/天的M17055具有剂量相关的利尿和降压作用。2.5 mg/kg/d和5 mg/kg/d剂量M17055显著（P < 0.01）降低了末次给药次日体重归一化的左心室重量。M17055与卡托普利在血压降低程度相同的情况下比较，M17055对心肌肥厚的影响比卡托普利更明显（P < 0.01）。通过胸主动脉和肠系膜上动脉第一分支的中腔/管腔比（M/L）评估血管肥大。在主动脉中，M17055在2.5和5 mg/kg/d剂量下，M/L略有降低，但不显著，而卡托普利则显著降低（P < 0.01）。在肠系膜动脉中，5 mg/kg/d剂量的M17055显著降低了该比值（P < 0.05）。上述结果提示M17055具有临床治疗高血压的有益作用。
We investigated the effects of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats (SHR). M17055 was orally administered once a day for 24 consecutive days to 14-week-old male SHR. M17055 at doses of 1.25, 2.5 and 5 mg/kg/day exerted a dose-related diuretic and antihypertensive effect during the treatment. The weight of the left ventricle normalized by body weight on the following day of the last dosage was significantly (P < 0.01) reduced by M17055 at doses of 2.5 and 5 mg/kg/day in a dose-dependent manner. The effect of M17055 on cardiac hypertrophy was more potent (P < 0.01) than that of captopril, when the comparison was performed at the doses of M17055 and captopril inducing the same extent of blood-pressure decrement. Vascular hypertrophy was evaluated by the media/lumen ratio (M/L) in the thoracic aorta and the first branch of the superior mesenteric artery. In the aorta, M/L was slightly, but not significantly, decreased by M17055 at doses of 2.5 and 5 mg/kg/day, whereas it was decreased significantly (P < 0.01) by captopril. In the mesenteric artery, the ratio was significantly (P < 0.05) reduced by M17055 at a dose of 5 mg/kg/day. These results suggest that M17055 possesses beneficial properties for the clinical treatment of hypertension.
组织肾素-血管紧张素系统的分子和生理学方面：强调心血管控制。
DOI：
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发表时间：
1988
期刊：
Journal of hypertension. Supplement : official journal of the International Society of Hypertension
影响因子：
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作者：
Dzau,VJ
通讯作者：
Dzau,VJ